Monthly Archives: November 2013

NONCODEv4: exploring the world of long non-coding RNA genes

NONCODE (http://www.noncode.org/) is an integrated knowledge database dedicated to non-coding RNAs (excluding tRNAs and rRNAs). Non-coding RNAs (ncRNAs) have been implied in diseases and identified to play important roles in various biological processes. Since NONCODE version 3.0 was released 2 years ago, discovery of novel ncRNAs has been promoted by high-throughput RNA sequencing (RNA-Seq). In this update of NONCODE, we ...

Read More »

Featured Long non-coding RNA: GHET1

Long noncoding RNAs (lncRNAs), a recently characterized class of noncoding RNAs, have been shown to have important regulatory roles and are deregulated in a variety of tumors. However, the contributions and functional mechanisms of lncRNAs to gastric carcinoma remain largely unknown. In this study, researchers at the Shanghai Jiao Tong University School of Medicine, China found that lncRNA gastric carcinoma ...

Read More »

Chromosome conformation capture-on-chip analysis of long-range cis-interactions of the SOX9 promoter

lncRNA

Evolutionarily conserved transcription factor SOX9 is essential for the differentiation of chondrocytes and the development of testes. Heterozygous point mutations and genomic deletions involving SOX9 lead to campomelic dysplasia (CD), a skeletal malformation syndrome often associated with sex reversal. Chromosomal rearrangements with breakpoints mapping up to 1.6 Mb up- and downstream to SOX9, and likely disrupting its distant cis-regulatory elements, ...

Read More »

Exiqon launches qPCR Array product for custom designed microRNA, mRNA and lncRNA assays

Exiqon A/S (NASDAQ OMX: EXQ), a leading supplier of high-value gene expression analysis products, today announced the launch of fully customizable qPCR arrays that allow for simultaneous detection of any microRNA, mRNA and lncRNA. As more scientists engage in next generation sequencing the need to verify gene expression discovered by sequencing grows. Researchers studying specific developmental or disease pathways are ...

Read More »

Long Noncoding RNAs Promote Transcriptional Poising of Inducible Genes

lncRNA

Long noncoding RNAs (lncRNAs) are a recently identified class of molecules that regulate the expression of protein-coding genes through a number of mechanisms, some of them poorly characterized. The GAL gene cluster of the yeast Saccharomyces cerevisiae encodes a series of three inducible genes that are turned on or off by the presence or absence of specific carbon sources in ...

Read More »

Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer

Long non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer. Highly upregulated in liver cancer (HULC), an lncRNA, has recently been revealed to be involved in hepatocellular carcinoma development and progression. It remains unclear, however, whether HULC plays an oncogenic role in human gastric cancer (GC). In the present study, researchers at the First Affiliated Hospital of Nanjing ...

Read More »

Featured lncRNA Position – Postdoctoral research fellow

Employer: University of Michigan Posted: October 20, 2013 Expires: December 18, 2013 Requisition number: Science jobs from University of Michigan: We are seeking highly motivated postdoctoral fellows to conduct research on: (1) long noncoding RNA in glucose and lipid metabolism, and (2) mechanisms of small secreted proteins in metabolic crosstalk and disease. Successful candidates will perform basic biomedical research in ...

Read More »

Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells

lncRNA

The mammalian genome harbors thousands of long noncoding RNA (lncRNA) genes. Recent studies have indicated the involvement of several of these lncRNAs in the regulation of gene expression. lncRNAs play crucial roles in various biological processes ranging from epigenetic gene regulation, transcriptional control, to post-transcriptional regulation. lncRNAs are localized in various subcellular compartments, and major proportion of these are retained ...

Read More »

Regional Epigenetic Down- and Up-Regulation in Cancer & lncRNAs with Potential Functionality

The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer. We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be ...

Read More »