Monthly Archives: October 2013

Evf2 lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes

lncRNA

Several lines of evidence suggest that long non-coding RNA (lncRNA)-dependent mechanisms regulate transcription and CpG DNA methylation. Whereas CpG island methylation has been studied in detail, the significance of enhancer DNA methylation and its relationship with lncRNAs is relatively unexplored. Previous experiments proposed that the ultraconserved lncRNA Evf2 represses transcription through Dlx6 antisense (Dlx6as) transcription and methyl-CpG binding protein (MECP2) ...

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Featured Long Non-Coding RNA – Urothelial Cancer Associated 1

long non-coding rna

The majority of the human genome is transcribed and generates non-coding RNAs (ncRNAs) that fail to encode protein information. Long non-coding RNAs (lncRNAs) are emerging as a novel class of ncRNAs, but our knowledge about these ncRNAs is limited. Previously, researchers at the Xi’an Jiaotong University, China had identified that a lncRNA, Urothelial cancer associated 1 (UCA1), played an important ...

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Garvan Institute receives grant to research role of long non-coding RNAs in Parkinson’s disease

lncrna

MEDIA RELEASE: 02 Oct 2013 The Michael J. Fox Foundation for Parkinson’s Research and Shake It Up Australia Foundation are co-funding a 12-month research project by Sydney’s Garvan Institute of Medical Research to look at the role of long non-coding RNAs in Parkinson’s disease. Long non-coding RNAs are complex molecules, produced from a DNA blueprint, that appear to play regulatory ...

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Identification of short-lived long non-coding RNAs as surrogate indicators for chemical stress response

Abiotic and biotic stressors in human cells are often a result of sudden and/or frequent changes in environmental factors. The molecular response to stress involves elaborate modulation of gene expression and is of homeostatic, ecological, and evolutionary importance. Although attention has primarily focused on signaling pathways and protein networks, long non-coding RNAs (ncRNAs) are increasingly involved in the molecular mechanisms ...

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Symposia: The Non-Coding Genome

E. Izaurralde, D. Bartel, J. Vogel, J. Rinn EMBL Heidelberg, Germany Wednesday 9 October – Saturday 12 October 2013 Download Poster Latest News Registration for this event is now open.  (please see the left menu Registration and Payment) Abstract deadline – 18 July 2013 Registration deadline – 22 August 2013 Get in contact with other participants of the symposium on ...

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Evolution of Alu elements in long non coding RNA and mRNA – Daniel Caffrey

Long non-coding RNAs (lncRNA) are a novel class of RNA molecule that are emerging as important regulators of gene transcription and post-transcriptional events. lncRNAs have been shown to regulate a broad variety of biological processes and are often located within regions of the genome that are associated with various diseases. Repetitive elements are a major component of lncRNA and their ...

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How to detect long non-coding RNA (lcnRNA)

from BitesizeBio According to the central dogma of molecular biology, DNA is transcribed into RNA, that is translated to proteins. Inconveniently, the vast majority of the genome contains sequences that do not actually code for proteins. So, this non-coding RNA (ncRNA) was dismissed as non-functional junk, letting researchers tick the box on their to-do lists and head off to the pub ...

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