Monthly Archives: October 2013

Long non-coding RNA HOTAIR in carcinogenesis and metastasis

lncRNA

Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression ...

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Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

lncRNA

Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. Researchers at the Mayo Clinic have identified lncRNA with highly conserved sequences, ultraconserved lncRNA (ucRNA) that are transcribed and altered in expression in HCC. Extracellular vesicles, such as exosomes and microvesicles, are released from tumor cells and can transfer biologically ...

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The vast, conserved mammalian lincRNome

lncRNA

Genome analysis of humans and other mammals reveals a surprisingly small number of protein-coding genes, only slightly over 20,000 (although the diversity of actual proteins is substantially augmented by alternative transcription and alternative splicing). Recent analysis of the mammalian genomes and transcriptomes, in particular, using the RNA-seq technology, shows that, in addition to protein-coding genes, mammalian genomes encode many long ...

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Workshop Proceedings – APPLICATIONS OF BIOINFORMATICS TO NON – CODING RNAS IN THE ERA OF NEXT – GENERATION SEQUENCIN G

Pacific Symposium on Biocomputing (PSB) 2014 January 3-7, 2014 The Big Island of Hawaii The human genome encodes a large number of non-coding RNAs, which employ a new and crucial layer of biological regulation in addition to proteins. Technical advancement in recent years, particularly, the wide application of next generation sequencing analysis, provide an unprecedented opportunity to identify new non-coding ...

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Emerging Trends of Long Non-coding RNAs in Gene Activation

lncRNA

RNA world has gained increasing importance in the recent past as its role beyond coding for proteins and components of translational machinery is becoming more and more prominent. Recent studies have shown pervasive transcription throughout the genome generating large number of non-coding RNAs (ncRNAs) but few of these RNAs have been shown to perform regulatory functions. Among these regulatory RNAs, ...

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Long Noncoding RNAs: Marching toward Mechanism

from The RNA Society Submit an abstract and register for Keystone Symposia’s conference on “Long Noncoding RNAs: Marching toward Mechanism,” that will take place February 27 – March 4, 2014 at the Eldorado Hotel & Spa in Santa Fe, New Mexico, USA. Scientific Organizers: Thomas R. Cech of HHMI/University of Colorado, Edith Heard of Institut Curie and Ronald R. Breaker ...

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Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs

Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic regulators of gene transcription. The diversity and complexity of lncRNA genes means that they exert their regulatory effects by a variety of mechanisms. Although there is still much to be learned about the mechanism of lncRNA function, general principles are starting to emerge. In particular, the application of high throughput ...

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Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect

Ventricular septal defects (VSD) are the most common form of congenital heart disease, which is the leading non-infectious cause of death in children; nevertheless, the exact cause of VSD is not yet fully understood. Long non-coding RNAs (lncRNAs) have been shown to play key roles in various biological processes, such as imprinting control, circuitry controlling pluripotency and differentiation, immune responses ...

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Long noncoding RNAs as metazoan developmental regulators

The study of long noncoding RNAs (lncRNAs) is still in its infancy with more putative RNAs identified than those with ascribed functions. Defined as transcripts that are longer than 200 nucleotides without a coding sequence, their numbers are on the rise and may well challenge protein coding transcripts in number and diversity. lncRNAs are often expressed at low levels and ...

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Non-coding RNAs in Prostate Cancer: the Long and the Short of it

lncRNA

As the leading culprit in cancer incidence for American men, prostate cancer continues to pose significant diagnostic, prognostic and therapeutic tribulations for clinicians. The vast spectrum of disease behavior warrants better molecular classification to facilitate the development of more robust biomarkers that can identify the more aggressive and clinically significant tumor subtypes that require treatment. The untranslated portion of the ...

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