Monthly Archives: September 2013

Featured long non-coding RNA – Hotdog

Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. Researchers at the Ecole Polytechnique Fédérale, Switzerland have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two ...

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Featured lncRNA Job – Research Assistant – California Institute of Technology

Job Number:103922066 Company Name:California Institute of Technology Location:Pasadena, CA Career Focus:Education, Training, & Library * Our group recently identified a new class of mammalian large non-coding RNA (lncRNAs) with important roles in biology and disease. These lncRNAs exert their regulatory influence on the genome in uncharacterized ways. We are looking for a highly motivated individual to join our integrative computational ...

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Long non-coding RNA expression profile in human gastric cancer and its clinical significances

lncRNA

Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression profile in gastric cancer and its potential clinical value. The global lncRNA expression profile in gastric cancer was measured by lncRNA microarray. The relationship between their levels ...

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Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA

Recent progress has been made in the identification of protein-coding genes and miRNAs that are expressed in and alter the behavior of colonic epithelia. However, the role of long non-coding RNAs (lncRNAs) in colonic homeostasis is just beginning to be explored. By gene expression profiling of post-mitotic, differentiated tops and proliferative, progenitor-compartment bottoms of microdissected adult mouse colonic crypts, we ...

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Origins of Genomic 'Dark Matter' Discovered

lncRNA

from Science Daily A duo of scientists at Penn State University has achieved a major milestone in understanding how genomic “dark matter” originates. This “dark matter” — called non-coding RNA — does not contain the blueprint for making proteins and yet it comprises more than 95 percent of the human genome. The researchers have discovered that essentially all coding and ...

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Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here researchers at the National Institutes of Health identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Their analysis revealed highly dynamic ...

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lncPro: for predicting lncRNA–protein interactions

lncRNA

Though most of the transcripts are long non-coding RNAs (lncRNAs), little is known about their functions. lncRNAs usually function through interactions with proteins, which implies the importance of identifying the binding proteins of lncRNAs in understanding the molecular mechanisms underlying the functions of lncRNAs. Only a few approaches are available for predicting interactions between lncRNAs and proteins. Now, a team ...

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Long non-coding RNAs: modulators of nuclear structure and function

lncRNA

Long non-coding (lnc)RNAs are emerging key factors in the regulation of various cellular processes. In the nucleus, these include the organization of nuclear sub-structures, the alteration of chromatin state, and the regulation of gene expression through the interaction with effector proteins and modulation of their activity. Collectively, lncRNAs form the core of attractive models explaining aspects of structural and dynamic ...

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Featured long non-coding RNA – H19

lncRNA

Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer. However, how H19 acts to regulate gene function has remained enigmatic, despite the recent implication of its encoded miR-675 in limiting placental growth. A team led by researchers at Yale University School of Medicine demonstrate ...

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Request for feedback on nomenclature of antisense bidirectional long non-coding RNA genes

The HUGO Gene Nomenclature Committee (HGNC) is the organisation responsible for naming human genes. In their current newsletter (http://www.genenames.org/hgncnews/hgnc-newsletter-summer-2013) they are asking the research community how they would like them to name bidirectional antisense lncRNA genes. It would be best if they could get feedback from as many interested lncRNA researchers as possible, so please check out the newsletter and ...

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