Monthly Archives: August 2013

Scientists at Genome Institute of Singapore Discover Gene that Controls the Birth of Neurons

By ACN Newswire – August 27, 2013 10:36 PM EDT Discovery of long non-coding RNA’s role in neurogenesis may lead to cures for diseases such as Alzheimer’s disease Singapore, Aug 28, 2013 – (ACN Newswire) – Scientists at A*STAR’s Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is ...

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Brain Function & Pathology: The Role of Long Non-coding RNAs in Neurobiology

Long non-coding RNAs (LncRNAs) have emerged recently as major players in governing fundamental biological processes. More than half of all known LncRNAs are expressed in the central nervous systems in mammals, and are found in different neuron types. The aberrant expression of LncRNAs has been associated with neurological disorders, such as Alzheimer’s. Since 2009, Arraystar has engineered microarrays for assessing ...

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A novel mechanism of gene regulation by lncRNAs in cancer progression

lncRNA

Long non-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various processes ranging from normal development to human diseases such as cancer progression. Recent studies have shown that lncRNAs regulate the gene expression by chromatin remodelling, transcription, splicing and RNA decay control, enhancer function, and epigenetic regulation. However, little is known about translation regulation ...

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Reactivation of the inactive X chromosome in development and reprogramming

lncRNA

In mammals, one of the two X chromosomes of female cells is inactivated for dosage compensation between the sexes. X chromosome inactivation is initiated in early embryos by the noncoding Xist RNA. Subsequent chromatin modifications on the inactive X chromosome (Xi) lead to a remarkable stability of gene repression in somatic cell lineages. In mice, reactivation of genes on the ...

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Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data

lncRNA

Long non-coding RNAs (lncRNAs) as a key group of non-coding RNAs have gained widely attention. Though lncRNAs have been functionally annotated and systematic explored in higher mammals, few are under systematical identification and annotation. Owing to the expression specificity, known lncRNAs expressed in embryonic brain tissues remain still limited. Considering a large number of lncRNAs are only transcribed in brain ...

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Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis

lncRNA

Differential abundance and activity of long noncoding RNAs (lncRNAs) are recognized as the hallmark features in various diseases. This review highlights the lncRNAs that play a functional role in the development of blood cells. Many lncRNAs and the protein complexes within which they interact have been implicated in various types of cancers. Multiple lncRNAs participate in normal and may be ...

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Long non-coding RNA – postdoctoral and staff positions are available

Postdoc positions are available in the McManus lab to study biological processes relating to noncoding RNA pathways.  If you are interested in conducting high-throughput genomic RNAi screens, or using the mouse as a model to understand noncoding RNA biology, this lab could be for you. We have a broad focus to understand the biology of gene expression as related to ...

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Featured long non-coding RNA – XACT

lncRNA

X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here researchers from Université Paris Diderot, France report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed ...

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Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulators of cell physiology, but it is yet unknown to what extent lncRNAs have evolved to be targeted by microRNAs. Comparative genomics has previously revealed widespread evolutionarily conserved microRNA targeting of protein-coding mRNAs, and here we applied a similar approach to lncRNAs. Researchers at the University of Gothenburg, Sweden used a map ...

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Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis

lncRNA

Skeletal muscle differentiation is orchestrated by a network of transcription factors, epigenetic regulators, and non-coding RNAs. The transcription factor Yin Yang 1 (YY1) silences multiple target genes in myoblasts (MBs) by recruiting Ezh2 (Enhancer of Zeste Homologue2). To elucidate genome-wide YY1 binding in MBs, we performed chromatin immunoprecipitation (ChIP)-seq and found 1820 specific binding sites in MBs with a large ...

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