Monthly Archives: June 2013

Science Gone Social

by Tracy Vence at Genetic Engineering News.com From keeping up with the literature to sparking collaborations and finding funds, scientists are storming social media. Not many scientists have produced manuscripts as a direct result of participating in discussions on social media. Fewer still support their research programs in full by funds obtained in the same way. But, respectively speaking, Emily ...

Read More »

Linc2GO: A Human LincRNA Function Annotation Resource Based On ceRNA Hypothesis

Large numbers of lincRNA (long intergenic non-coding RNA) have been detected through high-throughput sequencing technology. However, currently we still know very little about their functions. Therefore, a lincRNA function annotation database is needed to facilitate the study in this field. In this article, researchers from the Tsinghua University, China present Linc2GO, a web resource which aims to provide comprehensive functional ...

Read More »

Molecular Biology of Long Non-coding RNAs

Khalil, Ahmad M.; Coller, Jeff (Eds.) 2014, VI, 166 p. 18 illus., 16 illus. in color. ISBN 978-1-4614-8620-6 About this book ​​Brings together key experts in the field of lncRNAs Has appeal for basic scientists and clinicians Focuses on the recently discovered, and less understood, class of long non-coding RNAs Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm ...

Read More »

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

lncRNA

Neuropathic pain is a refractory disease characterized by maladaptive changes in gene transcription and translation in the sensory pathway. Long noncoding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs operate in the development of neuropathic pain is unclear. Here, researchers at Johns Hopkins University School of Medicine have identified a conserved lncRNA, named Kcna2 antisense ...

Read More »

A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure

lncRNA

Prader-Willi syndrome (PWS), a genetic disorder of obesity, intellectual disability and sleep abnormalities, is caused by loss of noncoding RNAs on paternal chromosome 15q11-q13. The imprinted minimal PWS locus encompasses a long non-coding RNA (lncRNA) transcript processed into multiple SNORD116 small nucleolar RNAs (snoRNAs) and the spliced exons of the host gene, 116HG. However, both the molecular function and disease ...

Read More »

No Junk DNA…It’s All Good!

from Zone in With Zon A Short Walk in the Wondrous, Wacky World of Long—and now Circular—Noncoding RNAs I’m pleased by how much I learn when researching topics for new content, and this was certainly the case for long noncoding RNA (lncRNA), which was briefly mentioned in my last blog post, “Ripples from the 2013 TIDES Conference.”  The topic piqued ...

Read More »

Reading DNA, backward and forward

lncRNA

MIT biologists reveal how cells control the direction in which the genome is read. by Anne Trafton, MIT News Office MIT biologists have discovered a mechanism that allows cells to read their own DNA in the correct direction and prevents them from copying most of the so-called “junk DNA” that makes up long stretches of our genome. Only about 15 ...

Read More »

Long noncoding RNAs: New regulators in plant development

lncRNA

Plant long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, especially in plant reproductive development and response to stresses. They are transcribed by RNA polymerase II (Pol II), Pol III and Pol V, and exert their functions by a variety of regulation pathways. In this review, the authors summarize the current knowledge of lncRNAs discoveries ...

Read More »

Targeting long non-coding RNAs in cancers: Progress and prospects

lncRNA

Pervasive transcription occurs in the human genome to generate thousands of RNA transcripts, and accumulating evidence suggested that the RNA molecules, without protein coding ability, have important roles in diverse biological functions. Long non-coding RNA (lncRNA), with size larger than 200nt, is a new class of the non-coding RNA that contributes to cancer development and progression. Roles for several lncRNAs ...

Read More »

Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer

lncRNA

Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in normal physiology and disease, our knowledge of cancer-related lncRNAs remains limited. By repurposing microarray probes, researchers at Tongji University, China constructed expression profiles of 10,207 lncRNA genes in approximately 1,300 tumors over four different cancer types. Through integrative analysis of the lncRNA expression profiles with clinical outcome and ...

Read More »