Monthly Archives: March 2013

Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells

Stem Cells

Maintenance of the pluripotent state or differentiation of the pluripotent state into any germ layer depend on factors that orchestrate expression of thousands of genes through epigenetic, transcriptional and post transcriptional regulation. Long noncoding RNAs (lncRNAs) are implicated in the complex molecular circuitry in developmental processes. The ENCODE project has opened up new avenues for studying these lncRNA transcripts with ...

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The roles of long noncoding RNA in epigenetic regulation

epigenetics & chromatin

Oral Presentation – from Epigenetics and Chromatin: Interactions and processes, Boston, MA, USA. 11-13 March 2013 The X-linked region now known as the ‘X-inactivation center’ (Xic) was once dominated by protein-coding genes but, with the rise of Eutherian mammals some 150-200 million years ago, became infiltrated by genes that produce long noncoding RNA (lncRNA). Some of the noncoding genes have ...

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Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury

brain injury

Over the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting as transcriptional and translational regulators. Non-coding RNAs, which can be sub-classified into long non-coding RNAs, microRNAs, PIWI-interacting RNAs and several others, are widely ...

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Featured Product – Knockdown and detection of lncRNA

Lincode

Thermo Scientific Lincode siRNA and Solaris lncRNA Expression Assays Comprehensive pre-designed reagents for investigation of human lncRNAs siRNAs with enhanced specificity from the RNAi leaders High-efficiency qPCR assays for specific and dependable lncRNA detection Lincode siRNAs have been created to support the growing interest in analysis of long noncoding RNAs (lncRNA). As with siGENOME and ON-TARGETplus siRNAs, which target protein-coding ...

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Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets

Comparing transcriptomic data with proteomic data to identify protein-coding sequences is a long-standing challenge in molecular biology, one that is exacerbated by the increasing size of high-throughput datasets. To address this challenge, and thereby to improve the quality of genome annotation and understanding of genome biology, researchers at The University of Queensland have developed an integrated suite of programs, called ...

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X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

x chomosome inactivation

X chromosome inactivation and genomic imprinting are classic epigenetic processes that cause disease when not appropriately regulated in mammals. Whereas X chromosome inactivation evolved to solve the problem of gene dosage, the purpose of genomic imprinting remains controversial. Nevertheless, the two phenomena are united by allelic control of large gene clusters, such that only one copy of a gene is ...

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