Monthly Archives: February 2013

Featured Long Non-coding RNA – ANCR

ANCR

Long non-coding RNAs (lncRNAs) are key regulators of diverse biological processes such as transcriptional regulation, cell growth and differentiation. Previous studies have demonstrated that the lncRNA-ANCR (anti-differentiation ncRNA) is required to maintain the undifferentiated cell state within the epidermis. However, little is known about whether ANCR regulates osteoblast differentiation. In this study, researchers at the Dental Clinic of Xuhui District, ...

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The Epigenetic Lnc

from The Scientist Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For example, after they are transcribed (pictured here) lncRNAs can direct epigenetic modification by becoming associated with methyltransferases—enzymes ...

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RegRNA 2.0 – an easy to use web server for identifying regulatory RNA motifs and functional sites

Functional RNA molecules participate in numerous biological processes, ranging from gene regulation to protein synthesis. Analysis of functional RNA motifs and elements in RNA sequences can obtain useful information for deciphering RNA regulatory mechanisms. A previous version, RegRNA, is widely used in the identification of regulatory motifs, and this work extends it by incorporating more comprehensive and updated data sources ...

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Long Non-Coding RNA in Cancer

lncRNA Cancer

Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. ...

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Featured long non-coding RNA – PTENpg1

PTENpg1

PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, researchers at the Karolinska Institutet, Sweden characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. They found two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, ...

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Wide-spread long non-coding RNAs (lncRNAs) as endogenous target mimics (eTMs) for microRNAs in plants

Target mimicry is a recently identified regulatory mechanism for microRNA functions in plants in which the decoy RNAs bind to microRNAs via sequence complementary therefore to block the interaction between microRNAs and their authentic targets. Both endogenous decoy RNAs (microRNA target mimics) and engineered artificial RNAs can induce target mimicry effects. Yet until now, only the IPS1 (Induced by Phosphate ...

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Peptide nucleic acid (PNA) based molecular beacons as diagnostic probes

Molecular Beacons

Although the function and mechanism of action of long non-coding RNAs (lncRNA) is still not completely known, studies have shown their potential role in the control of gene expression and regulation, in cellular proliferation and invasiveness at the transcriptional level via multiple mechanisms. Recently, colon cancer associated transcript 1 (CCAT1) lncRNA was found to be expressed in colorectal cancer (CRC) ...

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The regulation of mammalian mRNA transcription by lncRNAs: recent discoveries and current concepts

Transcription by RNA Pol II is a tightly controlled process that is critical to normal cellular metabolism. Understanding how transcriptional regulation is orchestrated has mainly involved identifying and characterizing proteins that function as transcription factors. During the past decade, however, an increasing number of lncRNAs have been identified as transcriptional regulators. This revelation has spurred new discoveries, novel techniques and ...

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Silencing by the imprinted Airn macro lncRNA

Airn

The majority of the mammalian genome is transcribed into long non-coding (lnc) RNAs, transcripts longer than 200 nucleotides and devoid of protein-coding potential. Recent genome-wide mapping efforts led to the identification of thousands novel lncRNAs, but so far only few have been functionally analyzed. Fifteen years ago, our group discovered Airn (antisense to Igf2r RNA non-coding), the first autosomal lncRNA ...

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Featured long non-coding RNA – Dlx1as

Dlx1as

Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with recent reports of a functional lncRNA encoded by the mouse Dlx5-Dlx6 locus, led researchers at the ...

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