Tag Archives: X-inactivation center

X-inactivation: xist RNA uses chromosome contacts to coat the X

The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action. In organisms with XY sex chromosomes, chromatin modifications are directed to the X chromosomes (X) to equalize X-linked ...

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