Tag Archives: University of Gothenburg

New lncRNA biomarkers for neuroblastoma

lncRNA

Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. “There is a need for new methods of treatment for high-risk patients, and that’s where our research can lead to ...

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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

lncRNA

Thousands of long non-coding RNAs (lncRNAs) lie interspersed with coding genes across the genome, and a small subset has been implicated as downstream effectors in oncogenic pathways. Here researchers from the University of Gothenburg make use of transcriptome and exome sequencing data from thousands of tumours across 19 cancer types, to identify lncRNAs that are induced or repressed in relation ...

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Post-doc position available in Long Noncoding RNA biology specializing in RNA epigenetics

lncRNA

Type of employment: Fixed-term employment, up to four years Extent: 100 % Location: Institute of Biomedicine, Gothenburg First day of employment: By agreement Reference number: PER 2016/266 Institute of Biomedicine is a huge super department with vast interest in several disciplines of biological research. It employs more than 400 people, including 110 PhD students. Insitute of Biomedicine is actively engaged ...

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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures

lncRNA

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. Researchers from the University of Gothenburg have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one of the chromatin-interacting lncRNAs, MEG3,  they explored the mechanisms by which lncRNAs target chromatin. ...

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Postdoc Position Available – Long Non-coding RNA

Postdoctoral fellow in Medical science, specifically bioinformatics and cancer genomics University of Gothenburg, Sweden Type of employment: Fixed-term employment, 2 years Extent: 100 % Location: Institute of Biomedicine, Gothenburg First day of employment: As agreed Reference number: PER 2014/466 The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge ...

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Comprehensive Analysis of Long Non-Coding RNAs in Ovarian Cancer Reveals Global Patterns and Targeted DNA Amplification

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as potent regulators of cell physiology, and recent studies highlight their role in tumor development. However, while established protein-coding oncogenes and tumor suppressors often display striking patterns of focal DNA copy-number alteration in tumors, similar evidence is largely lacking for lncRNAs. Here, a team led by researchers at University of Gothenburg, Sweden report on ...

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Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulators of cell physiology, but it is yet unknown to what extent lncRNAs have evolved to be targeted by microRNAs. Comparative genomics has previously revealed widespread evolutionarily conserved microRNA targeting of protein-coding mRNAs, and here we applied a similar approach to lncRNAs. Researchers at the University of Gothenburg, Sweden used a map ...

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miRcode – a map of putative microRNA target sites in the long non-coding transcriptome

Although small non-coding RNAs, such as microRNAs, have well-established functions in the cell, long non-coding RNAs (lncRNAs) have only recently started to emerge as abundant regulators of cell physiology, and their functions may be diverse. A small number of studies describe interactions between small and lncRNAs, with lncRNAs acting either as inhibitory decoys or as regulatory targets of microRNAs, but ...

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