Tag Archives: tumorigenesis

lncRNA HANR promotes tumorigenesis and increase of chemoresistance

lncRNA

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. In the current study, ...

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Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma

lncRNA

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

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Post-doc Position Available – Signal Transduction Laboratory

lncrna

LNCRNAS IN TUMORIGENESIS National Institute of Environmental Health Sciences, Research Triangle Park, NC Position Description: A postdoctoral position is available in the Signal Transduction Laboratory at the National Institute of Environmental Health Sciences (NIEHS), a major research institute of the NIH located in the research triangle park of North Carolina, in the group of Dr. Xiaoling Li. NIEHS offers an ...

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Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer

lncrna

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

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Affymetrix to Sponsor New Webinar Focusing on the Importance of Understanding lncRNAs in Breast Cancer Progression and Tumorigenesis

lncRNA

Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among women. Hundreds of thousands of women worldwide lose their battle against this cancer each year, and it is estimated that one in eight US women will develop invasive breast cancer in her lifetime. The heterogeneity of breast cancer, with its ...

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Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, Indiana University researchers analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. They revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) ...

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A cytoplasmic lncRNA correlates with triple-negative breast cancer

lncRNA

Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert their functions in many biological processes, their potential involvement in cytoplasmic signal transduction remains unexplored. Now, researchers from MD Anderson Cancer Center have identified a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by ...

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Relapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma

lncRNA

Increasing evidence has highlighted the important roles of dysregulated long non-coding RNA (lncRNA) expression in tumorigenesis, tumor progression and metastasis. However, lncRNA expression patterns and their prognostic value for tumor relapse in lung adenocarcinoma (LUAD) patients have not been systematically elucidated. In this study, researchers from Harbin Medical University evaluated lncRNA expression profiles by repurposing the publicly available microarray expression ...

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Featured Long Non-Coding RNA – BANCR

Long non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles in tumorigenesis and progression. However, their functions and downstream mechanisms are largely unknown. This study aimed to investigate whether BRAF-activated non-coding RNA (BANCR), a novel and potential regulator of melanoma cell, participates in the proliferation of malignant ...

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Featured long non-coding RNA – MEG3

Long noncoding RNAs (lncRNAs) have emerged recently as major players in governing fundamental biological processes, and many of which are altered in expression and likely to have a functional role in tumorigenesis. Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a lncRNA associated with various human cancers. However, its biological role and clinical significance ...

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