Tag Archives: transcriptomes

The vast, conserved mammalian lincRNome

lncRNA

Genome analysis of humans and other mammals reveals a surprisingly small number of protein-coding genes, only slightly over 20,000 (although the diversity of actual proteins is substantially augmented by alternative transcription and alternative splicing). Recent analysis of the mammalian genomes and transcriptomes, in particular, using the RNA-seq technology, shows that, in addition to protein-coding genes, mammalian genomes encode many long ...

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GraphClust – alignment-free structural clustering of local RNA secondary structures

GraphClust

Clustering according to sequence-structure similarity has now become a generally accepted scheme for ncRNA annotation. Its application to complete genomic sequences as well as whole transcriptomes is therefore desirable but hindered by extremely high computational costs. Now, researchers at University of Freiburg, Germany have developed a novel linear-time, alignment-free method for comparing and clustering RNAs according to sequence and structure. ...

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