Tag Archives: Telomeres

Basic biology and therapeutic implications of lncRNA

Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade. Extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining ...

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lncRNA TERRA RNA Antagonizes ATRX and Protects Telomeres

Through an integration of genomic and proteomic approaches to advance understanding of long noncoding RNAs, researchers from Harvard Medical School investigate the function of the telomeric transcript, TERRA. By identifying thousands of TERRA target sites in the mouse genome, they demonstrate that TERRA can bind both in cis to telomeres and in trans to genic targets. They then define a ...

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A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing lncRNA

lncRNA

Telomeres, the heterochromatic structures that protect the ends of the chromosomes, are transcribed into a class of long non-coding RNAs, telomeric repeat-containing RNAs (TERRA), whose transcriptional regulation and functions are not well understood. The identification of TERRA adds a novel level of structural and functional complexity at telomeres, opening up a new field of research. TERRA molecules are expressed at ...

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