Tag Archives: Shanghai Jiao Tong University School of Medicine

A stronger perturbation of lncRNAs expression may lead to the dysfunction of mitochondria in Down syndrome

lncrna

Trisomy 21 is the most common chromosomal disorder and underlies Down syndrome. Epigenetics, such as DNA methylation and post-translational histone modifications, plays a vital role in Down syndrome. However, the functions of epigenetics-related long noncoding RNAs (lncRNAs), found to have an impact on neural diseases such as Alzheimer’s disease, remain unknown in Down syndrome. In this study, researchers from Shanghai ...

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Three-lncRNA signature – a novel biomarker for the accurate prognosis prediction HNSCC

lncRNA

Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial ...

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Long Noncoding RNA ZFAS1 promotes the progression of colonic cancer

lncRNA

Long non-coding RNA ZFAS1 (zinc finger antisense 1) is frequently amplified in hepatocellular carcinoma and promotes metastasis by increasing zinc finger E-box binding homeobox 1 (ZEB1), which can potentiate the progression of epithelial-to-mesenchymal transition (EMT). However, the expression pattern and role of ZFAS1 in colonic cancer remains unknown. The present study aimed to investigate the role of ZFAS1 and its ...

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lncRNAs LOC146880 and ENST00000439577 may promote the progression of NSCLC

lncRNA

To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), researchers from the Shanghai Jiao Tong University School of Medicine analyzed microarray data on gene expression and methylation. Gene expression chip and HumanMethylation450BeadChip were used to interrogate genome-wide expression and methylation in tumor samples. Differential expression and methylation were analyzed through comparing tumors with adjacent ...

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Featured Long non-coding RNA: GHET1

Long noncoding RNAs (lncRNAs), a recently characterized class of noncoding RNAs, have been shown to have important regulatory roles and are deregulated in a variety of tumors. However, the contributions and functional mechanisms of lncRNAs to gastric carcinoma remain largely unknown. In this study, researchers at the Shanghai Jiao Tong University School of Medicine, China found that lncRNA gastric carcinoma ...

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