Tag Archives: Shanghai Institute of Biochemistry and Cell Biology

Unusual Processing Generates SPA lncRNAs that Sequester Multiple RNA Binding Proteins

lncRNA

Researchers from the Shanghai Institute of Biochemistry and Cell Biology identify a type of polycistronic transcript-derived long noncoding RNAs (lncRNAs) that are 5′ small nucleolar RNA (snoRNA) capped and 3′ polyadenylated (SPAs). SPA processing is associated with nascent mRNA 3′ processing and kinetic competition between XRN2 trimming and Pol II elongation. Following cleavage/polyadenylation of its upstream gene, the downstream uncapped pre-SPA ...

Read More »