Tag Archives: non-coding rnas

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed ...

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LncRNAs – macromolecules with big roles in neurobiology and neurological diseases

Long noncoding RNAs (lncRNAs) are recently defined as thousands of RNA molecules longer than 200 nucleotides and lacking an appreciable open reading frame in mammals. Although lncRNAs lack protein-coding function, they play critical roles in the regulation of almost all the protein-coding genes in a cell at various stages including chromatin modification, transcription and post-transcriptional processing. It is thus not ...

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Transposable elements (TEs) contribute to stress-related long intergenic noncoding RNAs in Plants

lncRNA

Noncoding RNAs have been extensively described in plant and animal transcriptomes by using high-throughput sequencing technology. Of these non-coding RNAs, a growing number of long intergenic noncoding RNAs (lincRNAs) have been described in multicellular organisms, however the origins and functions of many lincRNAs remain to be explored. In many eukaryotic genomes, transposable elements (TEs) are widely distributed and often account ...

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

lncRNA

Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure. Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in heart failure remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of ...

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Post-doc Position Available – Non-coding RNAs

lncRNA

Job Description A postdoctoral Associate position is available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in cancer (prostate and melanoma) metabolism in our laboratory at Sanford-Burnham Medical Discovery Institute, Orlando FL USA.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified (Mazar et al Mol. Cell. Biol 2016, Wei et al., JID 2016) in our ...

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Post-doc Positions Available – Karolinska Institutet

lncRNA

Applications are invited for up to three post-doctoral fellow positions in Gonçalo Castelo-Branco´s group, Karolinska Institutet, Stockholm, Sweden (http://ki.se/en/mbb/goncalo-castelo-branco-group) The post-doctoral positions are funded by an European Research Council (ERC) Consolidator Grant and aim at characterizing the molecular mechanisms of action of key transcription factors, ncRNAs and chromatin modifying enzymes, during oligodendrocyte linage progression during development and in disease models of multiple sclerosis. Technologies such ...

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Postdoc Position Available – mechanisms of RNA mediated epigenetic gene regulation

lncRNA

A Post Doctoral Fellow position is available in the laboratory of Dr. Kavitha Sarma. The lab investigates mechanisms of RNA mediated epigenetic gene regulation by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. Candidates with research interests in chromatin biology, epigenetics, and non-coding RNAs are encouraged to apply. A strong background in protein biochemistry ...

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Non-Coding RNAs in Cancer – An Interview with Dr. Martin Pichler

lncRNA

Professor Martin Pichler, who is the Collection Editor for the International Journal of Molecular Sciences Topical Collection of “Regulation by Non-Coding RNAs” [1]. Professor Martin Pichler, MD, MSc, received his MD at the Medical University of Graz, and his Master degree in Molecular Biology at the Karl-Franzens University Graz, Austria. Dr. Pichler continued his cancer research training in the laboratory ...

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Regulatory & Non-Coding RNAs

August 23 – 27, 2016 Abstract Deadline: June 2, 2016 Organizers: Victor Ambros, University of Massachusetts Medical School Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany Nicholas Proudfoot, University of Oxford, United Kingdom You are cordially invited to participate in a new conference on Regulatory & Non-Coding RNAs to be held at Cold Spring Harbor Laboratory. The opening session ...

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C-It-Loci – a knowledge database for tissue-enriched loci

lncRNA

Increasing evidences suggest that most of the genome is transcribed into RNAs, but many of them are not translated into proteins. All those RNAs that do not become proteins are called ‘non-coding RNAs (ncRNAs)’, which outnumbers protein-coding genes. Interestingly, these ncRNAs are shown to be more tissue specifically expressed than protein-coding genes. Given that tissue-specific expressions of transcripts suggest their ...

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