Tag Archives: ncRNA

UTA researchers discover connection between low oxygen levels and the lncRNA HOTAIR

lncrna

University of Texas at Arlington researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA. In a study ...

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IPMiner – to predict lncRNA-protein interactions

Non-coding RNAs (ncRNAs) play crucial roles in many biological processes, such as post-transcription of gene regulation. ncRNAs mainly function through interaction with RNA binding proteins (RBPs). To understand the function of a ncRNA, a fundamental step is to identify which protein is involved into its interaction. Therefore it is promising to computationally predict RBPs, where the major challenge is that ...

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)

Goteborg University (PER 2014/201) Title Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)  (PER 2014/201) Advertiser Goteborg University Role Postdoctoral Research Fellow Discipline Medicine & Health Location Gothenburg, Sweden Work Type Full Time, Fixed Term, 2 years Extent: 100 % Location: Institute of Biomedicine, Göteborg First day of employment: As agreed Reference number: PER 2014/201 The Institute of Biomedicine ...

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Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)

Goteborg University (PER 2014/201) Title Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)  (PER 2014/201) Advertiser Goteborg University Role Postdoctoral Research Fellow Discipline Medicine & Health Location Gothenburg, Sweden Work Type Full Time, Fixed Term, 2 years Extent: 100 % Location: Institute of Biomedicine, Göteborg First day of employment: As agreed Reference number: PER 2014/201 The Institute of Biomedicine ...

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Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk

Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. The ...

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An Integrated Analysis Method for miRNA, lncRNA and mRNA Profiles Based on Their Functional and Positional Relationships

lncRNA

ncRNAs have been identified as potential regulatory molecules and have multiple biological roles. Aberrant expression of specific ncRNAs contributes to multiple biological processes and many human diseases. Herein, researchers at the Nanjing Medical University simultaneously profiled miRNA, lncRNA and mRNA in human HepG2 and L02 cells applying high-throughput sequencing and micro-array technologies. Abnormal miRNA, lncRNA and mRNA profiles were assessed ...

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Emerging Trends of Long Non-coding RNAs in Gene Activation

lncRNA

RNA world has gained increasing importance in the recent past as its role beyond coding for proteins and components of translational machinery is becoming more and more prominent. Recent studies have shown pervasive transcription throughout the genome generating large number of non-coding RNAs (ncRNAs) but few of these RNAs have been shown to perform regulatory functions. Among these regulatory RNAs, ...

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Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs

Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic regulators of gene transcription. The diversity and complexity of lncRNA genes means that they exert their regulatory effects by a variety of mechanisms. Although there is still much to be learned about the mechanism of lncRNA function, general principles are starting to emerge. In particular, the application of high throughput ...

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Genetics Is Too Complex for Evolutionists to Fake It Anymore

lncRNA

from Evolution News & Views As David Klinghoffer noted the other day, a well-known science journalist has had it with evolutionary pretensions. It’s time to stop the “scientists now know” show and, rather, honestly “Celebrate the Unknowns.” This article deserves special emphasis — it’s that good. Writing in Nature on the 60th anniversary of the elucidation of the DNA molecule’s ...

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