Tag Archives: Nature

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

lncRNA

Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood. Here, through post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, researchers from UCLA interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden our understanding of molecular convergence ...

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The landscape of long noncoding RNAs in the human transcriptome

Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology and disease processes including cancer. To delineate genome-wide lncRNA expression, researchers at the University of Michigan curated 7,256 RNA sequencing (RNA-seq) libraries from tumors, normal tissues and cell lines comprising over 43 Tb of sequence from 25 independent studies. They applied ab initio assembly methodology to this data ...

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New Angelman syndrome therapy proposed

lncRNA

from UT San Diego by Bradley J. Fikes Isis Pharma approach helps mouse models of genetic disease A potential therapy for Angelman syndrome, a baffling genetic disease that impairs intellectual development, has been proposed by scientists including researchers at Isis Pharmaceuticals. The treatment, tested in mice, activates a gene that restores some of the neurological activity reduced in Angelman syndrome, ...

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Protracted Unrest Between ENCODE Researchers and Junk-DNA Advocates Goes On

lncRNA

from Evolution News and Views It’s not exactly Fergusson, Mo., but the battle between ENCODE researchers and junk-DNA holdouts goes on. Our ongoing coverage of the hostilities left off with the latter sending over their latest salvo. Now, ENCODE is back. Confident that genomes are not mostly junk, they have set their latest contender in the ring: a mouse. The ...

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Where long noncoding RNAs meet DNA methylation

DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site through the association of ecCEBPA with DNA methyltransferase 1, DNMT1. DNA methylation was ...

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Scientists shed some light on biological "dark matter"

from PYHS ORG Biologists have studied the functionality of a poorly understood category of genes, which produce long non-coding RNA molecules rather than proteins. Some of these genes have been conserved throughout evolution, and are present in 11 species ranging from man to frog. The research was lead at the University of Lausanne, in partnership with EPFL and the Swiss ...

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Scientists home in on a short list of interesting RNA ‘machines.’

lncRNA

Computer models plus observations of RNA inside a cell help scientists home in on a short list of interesting RNA ‘machines.’ by Elizabeth Dougherty, MIT News correspondent DNA stores the information of life, proteins provide the action, and in between sits elusive RNA, which serves both as a database of information and as a molecular machine. RNA is more flexible ...

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Origins of Genomic 'Dark Matter' Discovered

lncRNA

from Science Daily A duo of scientists at Penn State University has achieved a major milestone in understanding how genomic “dark matter” originates. This “dark matter” — called non-coding RNA — does not contain the blueprint for making proteins and yet it comprises more than 95 percent of the human genome. The researchers have discovered that essentially all coding and ...

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LncRNA, the Place to Be

from GenomeWeb The field of long non-coding RNAs is moving from the fringe into mainstream research, bringing a number of young researchers with it, writes Amy Maxmen at Nature. While there is enthusiasm for the field, she adds, lncRNA studies can still be difficult to tackle. “There are no optimized experimental protocols and few clues to the habits of individual ...

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RNA: The genome's rising stars

RNA

from Nature by Amy Maxmen When Saba Valadkhan lingered in the hallways at conferences, absorbed in discussions about the strands of ‘junk’ DNA that litter the human genome, she was not looking for work. She was consumed with curiosity about the possibility that long RNA sequences that do not encode proteins nevertheless have a function — enhancing or suppressing gene ...

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