Tag Archives: metastasis

The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer development and progression, including the metastatic spread of disease. Through in silico and biological analyses, investigators at Case Western Reserve University identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive breast cancer phenotypes, as well as with metastatic competence and disease recurrence in multiple clinical cohorts. ...

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Long noncoding RNAs in the progression, metastasis, and prognosis of osteosarcoma

lncRNA

lncRNAs are a large and diverse class of non-protein-coding transcripts longer than 200 nucleotides.lncRNAs have recently gained widespread attention and have been shown to have crucial roles in various biological regulatory processes. lncRNA sequences are conserved, and lncRNA expression profiles in adult tissues are broad. lncRNA messenger RNAs (mRNAs) are generally less abundant than protein-coding mRNAs but exhibit stronger tissue- ...

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lncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells

lncRNA

The present study intended to demonstrate the effects of long noncoding RNA growth arrest-specific transcript 5 (GAS5) on the migration and invasion of melanoma cells. Researchers at Kunming Medical University first detected the expression of GAS5 among four kinds of melanoma cell lines, followed by constructing GAS5-knocked down and overexpressed stable cells. Next, they evaluated the effects of GAS5 on ...

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Long noncoding RNA GAPLINC promotes invasion in colorectal cancer

lncRNA

This study aimed to investigate the role of long noncoding RNAs (lncRNAs) in the metastasis of colorectal cancer (CRC). Metastasis is an important prognostic factor of CRC, and lncRNAs have been implicated in tumor proliferation and metastasis. Genome-wide lncRNA expression patterns in metastatic lymph nodes compared with paired normal lymph nodes of CRC were assessed by microarray analysis. Gastric adenocarcinoma ...

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The lncRNA PAUPAR suppresses tumourigenesis in melanoma

lncRNA

Uveal melanoma (UM) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with UM develop metastases after diagnosis. Long non-coding RNAs (lncRNAs) are involved in both oncogenic and tumour suppression pathways. Researchers at Shanghai JiaoTong University School of Medicine show that lncRNA PAUPAR is present at low levels in UM tissues ...

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Long noncoding RNA DANCR promotes invasion of prostate cancer

LncRNA DANCR suppresses differentiation of epithelial cells, however, its function in prostate cancer development is still unknown. In the present study, researchers at Xi’an Jiaotong University found the expression of DANCR increases in prostate cancer tissues and cells compared to normal prostate tissues and cells, moreover, DANCR promotes invasion and migration of prostate cancer cells in vitro and metastasis of ...

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Aberrantly expressed lncRNAs may play an important role in the liver metastasis of colorectal cancer

The liver is the most frequent site of metastasis in colorectal cancer (CRC), in which long noncoding RNAs (lncRNAs) may play a crucial role. In this study, researchers from Zhejiang University performed a genome-wide analysis of lncRNA expression to identify novel targets for the further study of liver metastasis in CRC. Samples obtained from CRC patients were analyzed using Arraystar ...

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Long noncoding RNA SBF2-AS1 is upregulated in NSCLC and promotes proliferation of NSCLC tumor cells

lncRNA

Recent evidence has proven that long noncoding RNAs (lncRNAs) play important roles in cancer biology, while few lncRNAs have been characterized in NSCLC. Here, we characterized a novel lncRNA, SBF2 antisense RNA 1 (SBF2-AS1), in non-small cell lung cancer (NSCLC). Researchers at Nanjing Medical University used quantitative real-time PCR to quantify SBF2-AS1 expression in NSCLC tissues and cell lines. The ...

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Relapse-related long non-coding RNA signature to improve prognosis prediction of lung adenocarcinoma

lncRNA

Increasing evidence has highlighted the important roles of dysregulated long non-coding RNA (lncRNA) expression in tumorigenesis, tumor progression and metastasis. However, lncRNA expression patterns and their prognostic value for tumor relapse in lung adenocarcinoma (LUAD) patients have not been systematically elucidated. In this study, researchers from Harbin Medical University evaluated lncRNA expression profiles by repurposing the publicly available microarray expression ...

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Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor

lncRNA

Esophageal Squamous Cell Carcinoma (ESCC) is among the most common malignant cancers worldwide. In the past, extensive efforts have been made to characterize the involvement of protein-coding genes in ESCC tumorigenesis but few for long noncoding RNAs (lncRNAs). To investigate the transcriptome profile and functional relevance of lncRNAs, researchers at the Chinese Academy of Sciences performed an integrative analysis of ...

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