Tag Archives: long noncoding rna

Post-doc Positions Available – Bioinformatics and Cancer Cell Biology

lncRNA

Job Description Postdoctoral Associate positions (Bioinformatics and Cancer Cell Biology) are available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in our laboratory at Sanford-Burnham Medical Discovery Institute, Orlando FL USA.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified ( Lee et al Science Advances 2017 3(5): e1602505, Mazar et al Mol. Cell. Biol. ...

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Long noncoding RNAs coordinate functions between mitochondria and the nucleus

lncRNA

In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial-specific nucleic acids and proteins. To maintain homeostasis of the entire cell, an intense cross-talk between mitochondria and the nucleus, mediated by encoded noncoding RNAs (ncRNAs), as well as proteins, is required. Long ncRNAs (lncRNAs) contain characteristic structures, and they are involved ...

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Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing

lncRNA

The long non-coding RNA ANRIL, antisense to the CDKN2B locus, is transcribed from a gene that encompasses multiple disease-associated polymorphisms. Despite the identification of multiple isoforms of ANRIL, expression of certain transcripts has been found to be tissue-specific and the characterisation of ANRIL transcripts remains incomplete. Several functions have been associated with ANRIL. In our judgement, studies on ANRIL functionality ...

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Microarray profiling identifies long noncoding RNAs functionally involved in neurogenesis

lncRNA

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. Researchers from Nantong University aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential ...

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Post-doc Position Available – RNA Research

lncRNA

Job Title: Postdoctoral Associate (RNA Research) Pay Grade: r5 Pay Band Min / Max:  – Position Number: P100005691 Department / Hospital: Biochemistry & Molecular Biology 11 -STA   The University of Miami Miller School of Medicine’s Department of Biochemistry and Molecular Biology has an opportunity for a Post-Doctoral Associate under the supervision of Dr. Stephen Lee, Professor of Biochemistry and Molecular Biology. Research for ...

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lncRNA SNHG6 is a Potential Biomarker for Hepatocellular Carcinoma

lncRNA

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this ...

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Long noncoding RNA – a crosslink in biological regulatory network

lncRNA

Long noncoding RNAs (lncRNAs) had been defined as a novel class of functional RNAs longer than 200 nucleotides around a decade ago. It is widely acknowledged that lncRNAs play a significant role in regulation of gene expression, but the biological and molecular mechanisms are diverse and complex, and remain to be determined. Especially, the regulatory network of lncRNAs associated with ...

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Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

lncRNA

A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that tunes Foxp3 expression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of ...

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DES-ncRNA – A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining

lncRNA

Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding ...

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