Tag Archives: long non-coding RNA

Plasma long non-coding RNA MALAT1 is associated with distant metastasis

lncRNA

Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a newly identified metastasis-associated long non-coding RNA. In a previous study, it was identified that plasma levels of MALAT1 were significantly increased in gastric cancer patients with metastasis compared with gastric cancer patients without metastasis and healthy control individuals. However, it is unclear whether plasma levels of MALAT1 may act as a ...

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Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer

lncRNA

Multiple computational tools have been widely applied to the detection of coding driver mutations in cancer; however, the prioritization of pathogenic non-coding variants remains a difficult and demanding task. The present study was performed to distinguish non-coding disease-causing mutations from neutral ones, and to prioritize potential cancer-associated long non-coding RNAs (lncRNAs) with a logistic regression model in lung cancer. A ...

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Unraveling the oral cancer lncRNAome

lncRNA

The role of long non-coding RNA (lncRNA) expression in human head and neck squamous cell carcinoma (HNSCC) is still poorly understood. In this study, UCSD researchers aimed at establishing the onco-lncRNAome profiling of HNSCC and to identify lncRNAs correlating with prognosis and patient survival. The Atlas of Noncoding RNAs in Cancer (TANRIC) database was employed to retrieve the lncRNA expression ...

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Long non-coding RNAs – novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

lncRNA

Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 ...

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Call For Papers – Special Issue: Non-coding RNAs in Cancer

Editor: Aamir Ahmad, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Deadline: October 15th, 2016 Cancer is a deadly disease that affects millions of lives worldwide. The fight against cancer relies heavily on the availability of robust biomarkers for diagnosis, therapy and prognosis. In recent years, non-coding RNAs have attracted a lot of attention for their role in human cancers. The ...

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Role of long non-coding RNA in tumor drug resistance

lncRNA

Chemotherapy has been extensively used in tumor treatment, including either systemic or local treatment. Miserably, in many kinds of cancers, chemotherapy is gradually insensitive. The mechanisms of tumor drug resistance have been widely explored, yet have not been fully characterized. With several studies in the development of drug resistance, recent works have highlighted the involvement of non-coding RNAs in tumor ...

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Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures

lncRNA

Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure ...

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Featured lncRNA – Smooth Muscle Enriched Long Non-Coding RNA (SMILR)

lncRNA

Using RNA-sequencing, researchers from the University of Glasgow identified >300 lncRNAs whose expression was altered in human saphenous vein (HSV) VSMCs following stimulation with IL1α and PDGF. They focused on a novel lncRNA (Ensembl: RP11-94A24.1) which they termed smooth muscle induced lncRNA enhances replication (SMILR). Following stimulation, SMILR expression was increased in both the nucleus and cytoplasm, and was detected ...

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Long noncoding RNAs in lung cancer – what we know in 2015

lncRNA

Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological ...

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Hidden gene could help control anxiety

lncRNA

A new study has found the mechanism used by a hidden gene to affect how the brain responds to stressful experiences, in a discovery that could eventually help control anxiety. University of Queensland scientists, together with colleagues at the University of California Irvine and the Garvan Institute of Medical Research, discovered that Gomafu, a gene recently associated with schizophrenia, causes ...

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