Tag Archives: long non-coding RNA

Analysis of lncRNA MATLAT1 by In Situ Hybridization and Real-Time PCR

lncRNA

Long non-coding RNAs (lncRNAs) are important for transcription and for epigenetic or posttranscriptional regulation of gene expression and may contribute to carcinogenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNA involved in the regulation of the cell cycle, cell proliferation, and cell migration, is known to be deregulated in multiple cancers. Here, researchers from the University of Wisconsin School of Medicine ...

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Transcriptome analyses identifies long noncoding RNAs regulating energy metabolism

lncRNA

  Genome-wide screens define 359 metabolically sensitive lncRNAs in key metabolic organs LncRNA functions were predicted by mRNA-lncRNA correlation analyses In vitro assays connect lncRNAs to specific metabolic and signaling pathways SREBP1c induces Gm16551 to activate an lncRNA-mediated negative feedback loop       To systemically identify long noncoding RNAs (lncRNAs) regulating energy metabolism, researchers from the National Heart, Lung and ...

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The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer

lncRNA

Long non-coding RNAs (lncRNAs) have been shown to have crucial regulatory roles in human cancer biology. LncRNA PANDAR is a novel identified lncRNA that was previously reported to be increased in various cancers; however, its effect in colorectal cancer (CRC) remains unknown. The aim of this study was to explore the expression and role of lncRNA PANDAR in CRC. The ...

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MIT Team Shows How lncRNA Works

lncRNA

from Genetic Engineering News – Researchers at  MIT say they have deciphered the structure of one type of long noncoding RNA (lncRNA) and used that information to figure out how it interacts with a cellular protein to control the development of heart muscle cells. This is one of first studies to link the structure of lncRNAs to their function. “Emerging ...

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Androgen-responsive lncRNAs are diagnostic and prognostic markers for prostate cancer

lncRNA

Prostate cancer (PCa) is a leading cause of mortality among males. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that may act as biomarkers and therapeutic targets. In this study, researchers at Fudan University firstly conducted analysis of global lncRNA expression patterns by using their own cohort (GSE73397) and two public available gene expression datasets: The Cancer Genome Atlas ...

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Plasma long non-coding RNA MALAT1 is associated with distant metastasis

lncRNA

Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a newly identified metastasis-associated long non-coding RNA. In a previous study, it was identified that plasma levels of MALAT1 were significantly increased in gastric cancer patients with metastasis compared with gastric cancer patients without metastasis and healthy control individuals. However, it is unclear whether plasma levels of MALAT1 may act as a ...

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Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer

lncRNA

Multiple computational tools have been widely applied to the detection of coding driver mutations in cancer; however, the prioritization of pathogenic non-coding variants remains a difficult and demanding task. The present study was performed to distinguish non-coding disease-causing mutations from neutral ones, and to prioritize potential cancer-associated long non-coding RNAs (lncRNAs) with a logistic regression model in lung cancer. A ...

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Unraveling the oral cancer lncRNAome

lncRNA

The role of long non-coding RNA (lncRNA) expression in human head and neck squamous cell carcinoma (HNSCC) is still poorly understood. In this study, UCSD researchers aimed at establishing the onco-lncRNAome profiling of HNSCC and to identify lncRNAs correlating with prognosis and patient survival. The Atlas of Noncoding RNAs in Cancer (TANRIC) database was employed to retrieve the lncRNA expression ...

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Long non-coding RNAs – novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

lncRNA

Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 ...

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Call For Papers – Special Issue: Non-coding RNAs in Cancer

Editor: Aamir Ahmad, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Deadline: October 15th, 2016 Cancer is a deadly disease that affects millions of lives worldwide. The fight against cancer relies heavily on the availability of robust biomarkers for diagnosis, therapy and prognosis. In recent years, non-coding RNAs have attracted a lot of attention for their role in human cancers. The ...

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