Tag Archives: long non-coding RNA

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings

lncRNA

There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, a team led by researchers at the Second Military Medical University, China present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese population using RNA-seq, revealing tremendous diversity ...

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Featured long non-coding RNA – uc002mbe.2

uc002mbe.2

Differential expression of long non-coding RNAs (lncRNAs) plays critical roles in hepatocarcinogenesis. Considerable attention has focused on the antitumor effect of histone deacetylase inhibitor (Trichostatin A, TSA) as well as the coding gene expression-induced apoptosis of cancer cells. However, it is not known whether lncRNA has a role in TSA-induced apoptosis of human hepatocellular carcinoma (HCC) cells. The global expression ...

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Featured long non-coding RNA – HOXA-AS2

HOXA-AS2 lncRNA

HOXA cluster antisense RNA 2 (HOXA-AS2) is a long non-coding RNA located between the HOXA3 and HOXA4 genes in the HOXA cluster. Its transcript is expressed in NB4 promyelocytic leukemia cells and human peripheral blood neutrophils, and expression is increased in NB4 cells treated with all trans retinoic acid (ATRA). Knockdown of HOXA-AS2 expression by transduced shRNA decreases the number ...

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Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. Researchers at the Medical College of Soochow University, China  aimed to explore whether the expression of Long Non-Coding RNA (LncRNA) growth arrest-specific transcript 5 (GAS5) is associated with RCC genesis. They selected twelve clinical samples diagnosed for renal clear cell carcinoma and found that the LncRNA GAS5 transcript levels ...

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Featured long non-coding RNA – Gomafu

Gomafu

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, researchers from the University of Queensland, Australia profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically ...

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X-inactivation, imprinting, and long noncoding RNAs in health and disease

X chromosome inactivation and genomic imprinting are classic epigenetic processes that cause disease when not appropriately regulated in mammals. Whereas X chromosome inactivation evolved to solve the problem of gene dosage, the purpose of genomic imprinting remains controversial. Nevertheless, the two phenomena are united by allelic control of large gene clusters, such that only one copy of a gene is ...

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Cedric Notredame: “We want to understand under what pressure evolves long noncoding RNA”

According to the ENCODE‘s latest update in the human genome there are about 10,000 long sequences of RNA that do not code for any protein. Cedric Notredame’s lab at the Center for genomic Regulation (CRG) tries to detect these molecules not only in humans but also in other species to understand their functionality. Cedric Notredame explained his research at a ...

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Featured long non-coding RNA – Llme23

Several lines of evidence support the notion that increased RNA-binding ability of polypyrimidine tract-binding (PTB) protein-associated splicing factor (PSF) and aberrant expression of long non-coding RNAs (lncRNAs) are associated with mouse and human tumors. To identify the PSF-binding lncRNA involved in human oncogenesis, researchers at Sichuan University, China screened a nuclear RNA repertoire of human melanoma cell line, YUSAC, through ...

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The role of long non-coding RNA in transcriptional gene silencing

Transcriptional gene silencing controls the activity of transposable elements and expression of protein-coding genes. It requires non-coding transcription, which in plants is performed by RNA Polymerases IV and V (Pol IV and Pol V). Pol IV produces precursors for siRNA biogenesis while Pol V produces scaffold transcripts required for siRNAs and associated proteins to recognize their target loci. In this ...

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Advances in understanding chromosome silencing by the long non-coding RNA Xist

In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX females and XY males. X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied for half a century. In the last two decades, efforts have been focused on the X ...

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