Tag Archives: lncrna

Circulating long RNAs in serum extracellular vesicles: Their Characterization and Potential Application as Biomarkers for the Diagnosis of Colorectal Cancer

lncRNA

Long non-coding RNA and mRNAs are long RNAs (> 200 nucleotides) compared to microRNAs. In blood, long RNAs may be protected by serum extracellular vesicles, such as apoptotic bodies (ABs), microvesicles (MVs), and exosomes (EXOs). They are potential biomarkers for identifying cancer. Sera from 76 pre-operative CRC patients, 76 age- and sex-matched healthy subjects and 20 colorectal adenoma (CA) patients ...

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Exosomal Long Noncoding RNAs are Differentially Expressed in Cervical Cancer Patient Samples

lncRNA

As the second leading cause of cancer morbidity and death in women, cervical cancer remains an important public health problem worldwide. Novel biomarkers with high sensitivity and specificity for the early detection and diagnosis of cervical cancer are urgently needed. Increasing evidence shows that long noncoding RNAs (lncRNAs) are differentially expressed in cancer tissues and may serve as diagnostic markers. ...

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Long Non-coding RNAs in the Cytoplasm

lncRNA

Mammalian genome is pervasively transcribed into many different complex families of RNA. However, less than 2% of mammalian genome is transcribed into mRNA to encode proteins, whereas major portion of the genome is transcribed into interweaved and overlapping transcripts that include thousands of non-coding RNA (ncRNA) transcripts. ncRNAs more than 200 nucleotides in length are called long ncRNAs (lncRNAs), which ...

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NEAT1 is Required for Survival of Breast Cancer Cells

neat-feat

Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, cell growth, and apoptosis, as well as cancer metastasis and neurological disease progression; however, the mechanism of how lncRNAs regulate these processes is not well established. In this study, researchers from the Chinese Academy of Sciences demonstrated that downregulating ...

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Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types.

lncRNA

Long non-coding RNAs (lncRNAs) have been shown to contribute to tumorigenesis. However, surprisingly little is known about the comprehensive clinical and genomic characterization of lncRNAs across human cancer. In this study, researchers at Sun Yat-sen University conducted comprehensive analyses for the expression profile, clinical outcomes, somatic copy number alterations (SCNAs) profile of lncRNAs in ~7000 clinical samples from 15 different ...

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Knockdown of lncRNAs: exploring RNAi and antisense oligo methods

lncRNA

Thousands of different long non-coding RNAs (lncRNAs) exist in mammalian cells. lncRNAs do not encode proteins but can be very important for cell function. Studying their functions can be difficult because of their diverse modes of action. One method to discern cellular function is by selective knockdown of a specific lncRNA species. However, achieving consistent knockdown has proven to be ...

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Long non-coding RNA Databases in Cardiovascular Research

lncrna

With rising interest in the regulatory functions of long non-coding RNAs (lncRNAs) in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories specialized in lncRNAs have been developed, which make use of huge high-throughput data ...

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Long Non-Coding RNAs – Methods and Protocols

fish

The advent of next-generation sequencing revealed that the majority of the human genome is transcribed to noncoding RNAs. Recent studies on long noncoding RNAs (lncRNAs) suggest that they may represent another class of important, nonprotein regulators of various biological processes, including cell proliferation, differentiation, migration, apoptosis, and transformation. In this column of the Methods in Molecular Biology series, the authors ...

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Function of Mysterious RNAs May Often Lie in Their Genes

lncrna

Study co-led by Penn Medicine researcher shows non-coding DNA acting as enhancer of nearby gene’s expression PHILADELPHIA—A new genetic clue discovered by a team co-led by a researcher at the Perelman School of Medicine at the University of Pennsylvania is shedding light on the functions of the mysterious “long non-coding RNAs” (lncRNAs). These molecules are transcribed from genes and are ...

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Altered Long Noncoding RNA Expression Precedes the Course of Parkinson’s Disease

lncRNA

Parkinson’s disease (PD) is a slowly progressing neurodegenerative disorder that affects approximately seven million patients worldwide. Despite intensive research, the molecular mechanisms initiating and promoting PD are still unknown. However, it is assumed that environmental factors trigger PD. Recent research demonstrated that long noncoding RNAs (lncRNA) interfere in transcriptional and translational processes modulating gene expression reflecting environmental influences. Nevertheless, there ...

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