Tag Archives: lncrna

Investigation of novel LPS-induced differentially expressed long non-coding RNAs in endothelial cells

lncRNA

The molecular mechanisms responsible for sepsis-induced endothelial dysfunction leading to an elevated risk of cardiovascular diseases remain undefined. Endotoxic or septic shock is a potentially lethal complication of systemic infection by Gram-negative bacteria. Lipopolysaccharide (LPS) is a critical glycolipid component of the outer wall of Gram-negative bacteria, and many of the sepsis-associated cellular signals by Gram-negative bacteria are attributed to ...

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

lncRNA

Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure. Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in heart failure remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of ...

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RACE-Seq – extension of human lncRNA transcripts by RACE coupled with long-read high-throughput sequencing

rna-seq

Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of the mammalian transcriptome. Such characterization requires a comprehensive, high-quality annotation of their gene structure and boundaries, which is currently lacking. Here researchers from the Barcelona Institute of Science and Technology describe RACE-Seq, an experimental workflow designed to address this based on RACE (rapid amplification of cDNA ends) and ...

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The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation

lncRNA

Gastric cancer (GC) is the third leading cause of cancer death due to its poor prognosis and limited treatment options. Evidence indicates that pseudogene-derived long noncoding RNAs (lncRNAs) may be important players in human cancer progression, including GC. Researchers from the Nanjing Medical University report that a newly discovered pseudogene-derived lncRNA named DUXAP8, a 2107-bp RNA, was remarkably upregulated in ...

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Panel of five lncRNAs provides a signature for the diagnosis and prognosis of gastric cancer

lncRNA

Gastric cancer (GC) is one of the most aggressive malignancies and has a poor prognosis. Identifying novel diagnostic and prognostic markers is of great importance for the management and treatment of GC. Long non-coding RNAs (lncRNAs), which are involved in multiple processes during the development and progression of cancer, may act as potential biomarkers of GC. Here, by performing data ...

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Secondary structure impacts patterns of selection in human lncRNAs

lncRNA

Metazoans transcribe many long non-coding RNAs (lncRNAs) that are poorly conserved and whose function remains unknown. This has raised the questions of what fraction of the predicted lncRNAs is actually functional, and whether selection can effectively constrain lncRNAs in species with small effective population sizes such as human populations. Here researchers from the Centre for Genomic Regulation (CRG) evaluate signatures ...

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lncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells

lncRNA

The present study intended to demonstrate the effects of long noncoding RNA growth arrest-specific transcript 5 (GAS5) on the migration and invasion of melanoma cells. Researchers at Kunming Medical University first detected the expression of GAS5 among four kinds of melanoma cell lines, followed by constructing GAS5-knocked down and overexpressed stable cells. Next, they evaluated the effects of GAS5 on ...

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Long noncoding RNAs as novel predictors of survival in human cancer

lncRNA

Expression of various long noncoding RNAs (lncRNAs) may affect cancer prognosis. Researchers from Stanford University examined all evidence on the potential role of lncRNAs as novel predictors of survival in human cancer. The researchers systematically searched through PubMed, to identify all published studies reporting on the association between any individual lncRNA or group of lncRNAs with prognosis in human cancer ...

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Long noncoding RNA lincRNA-EPS as a repressor of inflammatory responses

lncRNA

Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, researchers at the University of Massachusetts Medical School identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely regulated in macrophages to control the expression of immune response genes (IRGs). Transcriptome analysis of macrophages from lincRNA-EPS-deficient ...

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