Tag Archives: lncrna

Transcriptome analyses identifies long noncoding RNAs regulating energy metabolism

lncRNA

  Genome-wide screens define 359 metabolically sensitive lncRNAs in key metabolic organs LncRNA functions were predicted by mRNA-lncRNA correlation analyses In vitro assays connect lncRNAs to specific metabolic and signaling pathways SREBP1c induces Gm16551 to activate an lncRNA-mediated negative feedback loop       To systemically identify long noncoding RNAs (lncRNAs) regulating energy metabolism, researchers from the National Heart, Lung and ...

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LINC00520 plays a functional role in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Harvard Medical School researchers performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, their analysis revealed a novel lncRNA, LINC00520 that is upregulated ...

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Comprehensive characterization of lncRNA-mRNA related ceRNA network across 12 major cancers

lncRNA

Recent studies indicate that long noncoding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs) to indirectly regulate mRNAs through shared microRNAs, which represents a novel layer of RNA crosstalk and plays critical roles in the development of tumor. However, the global regulation landscape and characterization of these lncRNA related ceRNA crosstalk in cancers is still largely unknown. Here, researchers ...

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Understanding long non-coding RNAs using comparative genomics

compare

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a multitude of pathways across species, but it remains challenging to understand which of them are important and how their functions are performed. Comparative sequence analysis has been instrumental for studying proteins and small RNAs, but the rapid evolution of lncRNAs poses new challenges that demand new ...

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Investigation of novel LPS-induced differentially expressed long non-coding RNAs in endothelial cells

lncRNA

The molecular mechanisms responsible for sepsis-induced endothelial dysfunction leading to an elevated risk of cardiovascular diseases remain undefined. Endotoxic or septic shock is a potentially lethal complication of systemic infection by Gram-negative bacteria. Lipopolysaccharide (LPS) is a critical glycolipid component of the outer wall of Gram-negative bacteria, and many of the sepsis-associated cellular signals by Gram-negative bacteria are attributed to ...

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

lncRNA

Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure. Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in heart failure remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of ...

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RACE-Seq – extension of human lncRNA transcripts by RACE coupled with long-read high-throughput sequencing

rna-seq

Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of the mammalian transcriptome. Such characterization requires a comprehensive, high-quality annotation of their gene structure and boundaries, which is currently lacking. Here researchers from the Barcelona Institute of Science and Technology describe RACE-Seq, an experimental workflow designed to address this based on RACE (rapid amplification of cDNA ends) and ...

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The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation

lncRNA

Gastric cancer (GC) is the third leading cause of cancer death due to its poor prognosis and limited treatment options. Evidence indicates that pseudogene-derived long noncoding RNAs (lncRNAs) may be important players in human cancer progression, including GC. Researchers from the Nanjing Medical University report that a newly discovered pseudogene-derived lncRNA named DUXAP8, a 2107-bp RNA, was remarkably upregulated in ...

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Panel of five lncRNAs provides a signature for the diagnosis and prognosis of gastric cancer

lncRNA

Gastric cancer (GC) is one of the most aggressive malignancies and has a poor prognosis. Identifying novel diagnostic and prognostic markers is of great importance for the management and treatment of GC. Long non-coding RNAs (lncRNAs), which are involved in multiple processes during the development and progression of cancer, may act as potential biomarkers of GC. Here, by performing data ...

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Secondary structure impacts patterns of selection in human lncRNAs

lncRNA

Metazoans transcribe many long non-coding RNAs (lncRNAs) that are poorly conserved and whose function remains unknown. This has raised the questions of what fraction of the predicted lncRNAs is actually functional, and whether selection can effectively constrain lncRNAs in species with small effective population sizes such as human populations. Here researchers from the Centre for Genomic Regulation (CRG) evaluate signatures ...

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