Tag Archives: lncrna

Long noncoding RNA lincRNA-EPS as a repressor of inflammatory responses

lncRNA

Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, researchers at the University of Massachusetts Medical School identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely regulated in macrophages to control the expression of immune response genes (IRGs). Transcriptome analysis of macrophages from lincRNA-EPS-deficient ...

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Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis

lncRNA

Long intergenic noncoding RNAs (lincRNAs) are a relatively new class of non-coding RNAs that have the potential as cancer biomarkers. To seek a panel of lincRNAs as pan-cancer biomarkers, researchers at the University of Hawaii at Manoa have analyzed transcriptomes from over 3300 cancer samples with clinical information. Compared to mRNA, lincRNAs exhibit significantly higher tissue specificities that are then ...

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines

lncRNA

Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and microRNAs. However, there is limited data on the role and expression of long noncoding RNAs (lncRNAs) in prostate cancer exosomes. Researchers from the ...

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Environmental Health and Long Non-coding RNAs

lncRNA

An individual’s risk of developing a common disease typically depends on an interaction of genetic and environmental factors. Epigenetic research is uncovering novel ways through which environmental factors such as diet, air pollution, and chemical exposure can affect our genes. DNA methylation and histone modifications are the most commonly studied epigenetic mechanisms. The role of long non-coding RNAs (lncRNAs) in ...

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spongeScan – a graphical web tool for detecting microRNA binding elements in lncRNA sequences

lncRNA

Non-coding RNA transcripts such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are important genetic regulators. However, the functions of many of these transcripts are still not clearly understood. Recently, it has become apparent that there is significant crosstalk between miRNAs and lncRNAs and that this creates competition for binding between the miRNA, a lncRNA and other regulatory targets. Indeed, ...

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Long noncoding RNAs in cancer

lncRNA

Some lncRNAs associated with cancers. The colour represents either upregulated (red) or downregulated (blue) compared to normal tissues Large-scale cDNA sequencing projects, together with technological advancements such as tiling arrays and the next generation RNA sequencing provided an unprecedented view of the transcriptome complexity. Surprisingly, only 1–2 % of the whole genome encodes proteins, with evidence of at least 80 % of ...

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A functional GBM long non-coding RNA-mediated competitive endogenous RNA network

lncRNA

Glioblastoma multiforme (GBM) is a highly malignant brain tumor associated with a poor prognosis. Cross-talk between competitive endogenous RNAs (ceRNAs) plays a critical role in tumor development and physiology. In this study, researchers at Xiangya Hospital present a multi-step computational approach to construct a functional GBM long non-coding RNA (lncRNA)-mediated ceRNA network (LMCN) by integrating genome-wide lncRNA and mRNA expression ...

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Long non-coding RNAs as novel therapeutic targets in cancer

lncRNA

As a result of the explosion of large-scale genome sequencing projects, we have gained great insights into the evolution of complex organisms. Perhaps, one of the most unexpected outcomes of these studies was that the human genome contains only about 20,000 protein-coding genes, which occupy less than 3% of human DNA. Most of these genes also appear rather well conserved ...

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Circulating long RNAs in serum extracellular vesicles: Their Characterization and Potential Application as Biomarkers for the Diagnosis of Colorectal Cancer

lncRNA

Long non-coding RNA and mRNAs are long RNAs (> 200 nucleotides) compared to microRNAs. In blood, long RNAs may be protected by serum extracellular vesicles, such as apoptotic bodies (ABs), microvesicles (MVs), and exosomes (EXOs). They are potential biomarkers for identifying cancer. Sera from 76 pre-operative CRC patients, 76 age- and sex-matched healthy subjects and 20 colorectal adenoma (CA) patients ...

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