Tag Archives: lncrna

LncRNA Transcriptional Control of Inflammatory Responses

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. LncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and ...

Read More »

The lncRNA AK144841 could contribute to molecular cascades leading to tumor development

lncRNA

Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. Researchers from Universite Cote d Azur demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a ...

Read More »

Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

lncrna

Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the pluripotent state. In ESCs, Cyrano is a stably expressed long intergenic noncoding RNA with no previously assigned role. Researchers from the University ...

Read More »

lncRNA-screen – an interactive platform for computationally screening long non-coding RNAs in large genomics datasets

lncrna

Long non-coding RNAs (lncRNAs) have emerged as a class of factors that are important for regulating development and cancer. Computational prediction of lncRNAs from ultra-deep RNA sequencing has been successful in identifying candidate lncRNAs. However, the complexity of handling and integrating different types of genomics data poses significant challenges to experimental laboratories that lack extensive genomics expertise. To address this ...

Read More »

Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer

lncRNA

Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, researchers from the Chinese Academy of Sciences and Fudan University analyzed lncRNA expression profiles of 493 ...

Read More »

Global ID of lncRNAs associated with insecticide resistance in diamondback moths

Long noncoding RNAs (lncRNAs) are now considered important regulatory factors, with a variety of biological functions in many species including insects. Some lncRNAs have the ability to show rapid responses to diverse stimuli or stress factors and are involved in responses to insecticide. However, there are no reports to date on the characterization of lncRNAs associated with chlorantraniliprole resistance in ...

Read More »

Researchers identify cancer-related long noncoding RNAs in quintuple-negative lung adenocarcinoma

lncRNA

Lung adenocarcinoma (LUAD) is a common subtype of non-small cell lung cancer prevalent in Asia. There is a dearth of understanding regarding the transcriptome landscape of LUAD without primary known driver mutations. In this study, researchers at MSD China R&D used LUAD samples without well-known driver mutations occurring in EGFR, KRAS, ALK, ROS1 or RET (quintuple-negative) for transcriptome study with ...

Read More »

The Function and Clinical Implications of Long Non-Coding RNAs in Melanoma

lncRNA

Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic) regulation of cell growth, invasion, and other important cellular functions. Consequently, recent ...

Read More »

The lncRNome of head and neck squamous cell carcinomas

Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatics procedures predict the existence of tens of thousands of lncRNAs, from which we know the functions of only a handful of them, and very little is known in cancer types such as head and ...

Read More »

Impact of Dietary Interventions on Noncoding RNA Networks

lncRNA

Dietary interventions dramatically affect metabolic disease and lifespan in various aging models. Here, researchers from the Shanghai Institutes for Biological Sciences profiled liver microRNA (miRNA), coding, and long non-coding RNA (lncRNA) expression by high-throughput deep sequencing in mice across multiple energy intake and expenditure interventions. Strikingly, three dietary intervention network design patterns were uncovered: (1) lifespan-extending interventions largely repressed the ...

Read More »