Tag Archives: inflammation

LncRNA Transcriptional Control of Inflammatory Responses

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. LncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and ...

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De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood

lncrna

Long intergenic noncoding RNAs (lincRNAs) have emerged as key regulators of cellular functions and physiology. Yet functional lincRNAs often have low, context-specific and tissue-specific expression. Researchers from Columbia University Medical Center hypothesized that many human monocyte and adipose lincRNAs would be absent in current public annotations due to lincRNA tissue specificity, modest sequencing depth in public data, limitations of transcriptome assembly ...

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LncRNA – a versatile regulator of the NF-κB signaling circuit

lncRNA

The Nuclear Factor-κB (NF-κB) family of transcription factors play an essential role for the regulation of inflammatory responses, immune function and malignant transformation. Aberrant activity of this signaling pathway may lead to inflammation, autoimmune diseases and oncogenesis. Over the last two decades great progress has been made in the understanding of NF-κB activation and how the response is counteracted for ...

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lncRNAs Maintain Equilibrium Between Fighting Infection, Inflammatory Havoc

lncRNA

Penn Study Identifies New Drug Target for Inflammatory Disorders PHILADELPHIA – Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of ...

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Long non-coding RNA a potential therapeutic target for certain inflammatory disorders

lncRNA

A long non-coding RNA, Morrbid, controls how long circulating myeloid cells live, which is key to maintaining the proper balance between fighting infection and exacerbating inflammation. The discovery offers a potential therapeutic target for certain inflammatory disorders, such as asthma, Churg-Strauss syndrome and hypereosinophilic syndrome, that are characterized by abnormal myeloid cell lifespan. Circulating myeloid cells (neutrophils, eosinophils and so-called “classical” ...

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Post-doc Position Available – Long non-coding RNA and Nuclear Hormone Receptor Regulation

lncRNA

A post-doc opportunity to make a real difference to the future of medical science. If you are a talented, highly motivated, postdoctoral scientist, and are ready to play your part in the future of scientific innovation, we have a role for you.  The position is embedded within our prestigious academic-style postdoctoral program, with the primary objective of undertaking and publishing ...

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The role of noncoding RNA in vascular remodelling

lncRNA

Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling. In this review, researchers from the Glasgow Cardiovascular Research Centre highlight recent studies that demonstrate the involvement of ncRNAs in vein graft disease, in in-stent restenosis and in pulmonary arterial hypertension, with a particular focus on endothelial ...

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Long noncoding RNA found to quell inflammation

lncRNA

UMass Medical School researchers implicate lincRNA in immune system A long noncoding RNA (lincRNA)—called lincRNA-EPS—responsible for regulating innate immunity has been identified by a team of scientists at UMass Medical School. The findings were published in Cell. Katherine A. Fitzgerald, PhD, professor of medicine, is senior author on the study. Abundantly found in macrophages, lincRNA-EPS keeps the genes that trigger ...

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Does lncRNA Explain Inflammation in RA & Lupus?

lncRNA

Understanding DNA is often viewed as the key to understanding how the human body works, but what if it is actually RNA? Susan Carpenter, PhD of the University of California, Santa Cruz talks with us about her research into long non-coding RNA, and how this foundational science will hopefully lead to a better understanding of inflammation in the human body, ...

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Missing links in cardiology: long non-coding RNAs enter the arena

Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts that can regulate gene expression and may have many more ...

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