Tag Archives: HOTAIR

Post-doc position available – bioinformatics of long noncoding RNAs

lncrna

The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases. We are particularly interested in studying RNA-DNA interactions as mechanisms of transcriptional control. For example, we have recently shown how the long-noncoding RNA HOTAIR interacts with DNA via triple helices to control ...

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UTA researchers discover connection between low oxygen levels and the lncRNA HOTAIR

lncrna

University of Texas at Arlington researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA. In a study ...

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Plasma lncRNA HOTAIR could serve as a promising biomarker for diagnosing and monitoring NSCLC

lncrna

Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR) has been reported to play a vital role in various cancers. It has been found that HOTAIR was upregulated in non-small cell lung cancer (NSCLC) and involved in cell invasion and metastasis. The aberrant expression of HOTAIR is expected to serve as a potential biomarker for patients with NSCLC. ...

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ASSA – Transcriptome-Wide Prediction Of lncRNA-RNA Interactions By Thermodynamics

lncRNA

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them function post-transcriptionally via formation of inter-molecular duplexes. Sequence alignment tools are frequently used for transcriptome-wide prediction of RNA-RNA interactions. However, such approaches have poor prediction accuracy since they ignore RNA secondary structure and interaction energy. ...

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Long Non-coding RNAs in Gastric Cancer: A True Relationship or miR Chance?

Long non-coding RNAs (lncRNAs) are gradually drawing the attention of the cancer research community due to their pivotal involvement in tumorigenesis and tumor progression. These non-protein coding, >200 nucleotides long transcripts are aberrantly expressed in the majority of human malignancies, including gastric cancer (GC). The discovery that lncRNAs are severely deregulated across different human malignancies has prompted the pursuit of ...

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The lncRNA HOTAIR impacts differentiation of mesenchymal stem cells via triple helix formation

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, researchers from RWTH University Medical School analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increasing cell culture ...

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MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Prostate Cancer Cells

In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs) are emerging as critical determinants of hormone action. Here researchers from the Institute of Cell Biology and Neurobiology, Rome investigated the involvement of selected cancer-associated lncRNAs in Estrogen Receptor (ER) signaling. Prior studies by Chromatin Immunoprecipitation (ChIP) Sequencing showed that in prostate cancer cells ERs form a ...

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The emerging role of long non-coding RNAs in endometrial cancer

lncRNA

The human genome is pervasively transcribed and approximately 98% of the genome is non-coding. Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, lncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes ...

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Researchers use a novel bioinformatics tool for identification of the triple helix forming potential of lncRNA HOTAIR

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, researchers from RWTH University Medical School analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increasing cell culture ...

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