Tag Archives: gene regulation

Post-doc Position Available – Digestive Diseases

lncRNA

David Geffen School Of Medicine – Medicine-Gastroenterology Recruitment Period – Open August 17th, 2017 through November 17th, 2017 Description The Padua lab has a keen interest in understanding gene regulation and signaling pathways in the context of complex biological phenomena. Our clinical interests are in inflammatory bowel disease (IBD) and colon cancer diagnosis. One focus of the lab will be ...

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Post-doc Position Available – Molecular Mechanisms of Gene Regulation

lncRNA

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by long noncoding RNAs (lncRNAs). Project Details Over 70% ...

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Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

lncRNA

A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA) Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that tunes Foxp3 expression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of ...

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Post-doc Position Available – Molecular Mechanisms of Gene Regulation

lncRNA

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Posting Open Date: 03/02/2016 Open Until Filled: Yes Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by ...

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Researchers describe the first use of spherical nucleic acids as nanoparticle platform for regulating lncRNAs in cells

Emerging evidence indicates that long noncoding RNAs (lncRNAs) are actively involved in a number of developmental and tumorigenic processes. Here, Northwestern University researchers describe the first successful use of spherical nucleic acids as an effective nanoparticle platform for regulating lncRNAs in cells; specifically, for the targeted knockdown of the nuclear-retained metastasis associated lung adenocarcinoma transcript 1 (Malat1), a key oncogenic ...

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Mining long noncoding RNA in livestock

lncRNA

Genome-wide association studies in livestock based on high-resolution genotyping and sequencing have revealed that the majority of signals associated with complex phenotypic traits are located outside of annotated protein-coding regions in the genome. The approaches of next-generation sequencing applied to whole transcriptome and chromatin profiles have provided information about existing genome-wide transcriptional activity and have revealed that the genomes are ...

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Post-doc Position Available – Molecular Mechanisms of Gene Regulation

lncRNA

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Posting Open Date: 03/02/2016 Open Until Filled: Yes Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by ...

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Postdoc Position Available – Gene Regulation Induced by Long Noncoding RNAs

Position Information Position Title Postdoctoral Research Associate_Calabrese Lab Vacancy ID PDS001253 Department Pharmacology – 424001 Position Type Postdoctoral Scholar Posting Details Salary Range Full-time/Part-time Full Time If part-time, hours per week FTE 1.0 Proposed Start Date Estimated Duration of Appointment 12 Months Posting Open Date 03/02/2016 Posting Close Date Open Until Filled Yes Work Location Chapel Hill, NC Position Summary ...

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Long non-coding RNA Databases in Cardiovascular Research

lncrna

With rising interest in the regulatory functions of long non-coding RNAs (lncRNAs) in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories specialized in lncRNAs have been developed, which make use of huge high-throughput data ...

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Role of the lncRNA-p53 regulatory network in cancer

lncRNA

Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor ...

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