Tag Archives: epigenetics

LncRNA Transcriptional Control of Inflammatory Responses

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. LncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and ...

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Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

lncRNA

Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and researchers from the University of ...

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Post-doc Position Available – RNA Biochemistry

lncRNA

Job description LANL has an intellectually diverse environment and demands creative, innovative and pioneering solutions. LANL is multidisciplinary with expertise in chemistry, materials science, bioscience, physics, engineering, computer science, social science and many other fields. As a national laboratory, high priority is placed in interdisciplinary studies. Facilities include a large number of supercomputers, high-throughput biochemistry, and next-generation sequencing, as well ...

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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

lncRNA

The angiogenic function of endothelial cells is regulated by numerous mechanisms but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. Goethe-University researchers set out to identify novel and functionally important endothelial lncRNAs. Epigenetically controlled lncRNAs in human umbilical vein endothelial cells (HUVEC) were searched by exon-array analysis after knockdown of the histone demethylase JARID1B. Molecular mechanisms were ...

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Genetic variation in long noncoding RNAs and the risk of nonalcoholic fatty liver disease

lncRNA

The human transcriptome comprises a myriad of non protein-coding RNA species, including long noncoding RNAs (lncRNAs), which have a remarkable role in transcriptional and epigenetic regulation. Researchers at the University of Buenos Aires hypothesized that variants in lncRNAs influence the susceptibility to nonalcoholic fatty liver disease (NAFLD). Using next generation sequencing, they performed a survey of genetic variation associated with randomly ...

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Post-doc position available – lncRNAs in epigenetics

lncRNA

LANL has an intellectually diverse environment and demands creative, innovative and pioneering solutions. LANL is multidisciplinary with expertise in chemistry, materials science, bioscience, physics, engineering, computer science, social science and many other fields. As a national laboratory, high priority is placed in interdisciplinary studies. Facilities include a large number of supercomputers, high-throughput biochemistry, and next-generation sequencing, as well as many ...

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Study unveils hidden molecular machinery in RNA processes

lncRNA

A special stretch of ribonucleic acid (RNA) called COOLAIR is revealing its inner structure and function to scientists, displaying a striking resemblance to an RNA molecular machine, territory previously understood to be limited to the cells’ protein factory (the ‘ribosome’) and not a skill set given to mere strings of RNA. “We are uncovering the nuts and bolts of plant ...

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Environmental Health and Long Non-coding RNAs

lncRNA

An individual’s risk of developing a common disease typically depends on an interaction of genetic and environmental factors. Epigenetic research is uncovering novel ways through which environmental factors such as diet, air pollution, and chemical exposure can affect our genes. DNA methylation and histone modifications are the most commonly studied epigenetic mechanisms. The role of long non-coding RNAs (lncRNAs) in ...

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Postdoc Position Available – mechanisms of RNA mediated epigenetic gene regulation

lncRNA

A Post Doctoral Fellow position is available in the laboratory of Dr. Kavitha Sarma. The lab investigates mechanisms of RNA mediated epigenetic gene regulation by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. Candidates with research interests in chromatin biology, epigenetics, and non-coding RNAs are encouraged to apply. A strong background in protein biochemistry ...

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Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases

lncRNA

Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, the authors summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), ...

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