Tag Archives: epigenetic

Genome-wide discovery of long intergenic noncoding RNAs

lncRNA

Long intergenic noncoding RNAs (lincRNAs) play a crucial role in many biological processes. The rat is an important model organism in biomedical research. Recent studies have detected rat lincRNA genes from several samples. However, identification of rat lincRNAs using large-scale RNA-seq datasets remains unreported. Herein, using more than 100 billion RNA-seq reads from 59 publications together with RefSeq and UniGene ...

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Post-doc Position Available – Epigenetic Alteration of Long Non-coding RNA

lncRNA

Ref. : 201601691 Posting Title : Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA Department : Department of Medicine Closing Date : April 13, 2017 Applications are invited for appointment as Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA in the Department of Medicine, to commence as soon as possible for three years, with the possibility of renewal. ...

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Biological ‘dark matter’ molecule plays surprise role in heart failure

lncRNA

Discovery may help scientists develop effective therapies to prevent or reverse this common and often fatal disease from the UCLA Newsroom by Jim Schnabel – Scientists at UCLA have identified a molecule that appears to play a key role in the development of heart failure. The scientists found that blocking the molecule, known as chaer, in animal studies prevented the ...

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Comprehensive analysis of epigenetic pattern of long noncoding RNA loci in colorectal cancer

lncRNA

Colorectal cancer (CRC) is one of the most common and severe cancers worldwide. The occurrence of CRC is developed by accumulation of genetic and epigenetic alteration in colon cells. Work over the last decade has proposed that epigenetic changes such as DNA methylation, histone modification of protein coding genes play an important role in CRC development. However, the epigenetic pattern ...

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The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

lncRNA

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here a team led by researchers at UCLA identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), which is necessary for the development of cardiac hypertrophy. Mechanistically, Chaer directly interacts with the catalytic subunit ...

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Role of Long non-coding RNAs in Epigenetic Regulation

The main function of lncRNA in regulation is to control expression of defined genes. For their role in development, they modulate chromatin structure recruiting epigenetic modification proteins to defined sites of the genome. Examples of this function are HOTAIR, Xist and Kcnqot1. HOTAIR is involved in limb formation and cancer meanwhile Kcnqot1 is involved with the imprinting of its loci…

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A genomic screen for long noncoding RNA genes epigenetically silenced in colorectal cancer

lncRNA

Long noncoding RNAs (lncRNAs) have emerged as key components in multiple cellular processes, although their physiological and pathological functions are not fully understood. To identify cancer-related lncRNAs, researchers at the Sapporo Medical University screened for those that are epigenetically silenced in colorectal cancer (CRC). Through a genome-wide analysis of histone modifications in CRC cells, they found that the transcription start ...

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Long noncoding RNA DANCR promotes invasion of prostate cancer

LncRNA DANCR suppresses differentiation of epithelial cells, however, its function in prostate cancer development is still unknown. In the present study, researchers at Xi’an Jiaotong University found the expression of DANCR increases in prostate cancer tissues and cells compared to normal prostate tissues and cells, moreover, DANCR promotes invasion and migration of prostate cancer cells in vitro and metastasis of ...

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Role of Long non-coding RNAs in Epigenetic Regulation

The main function of lncRNA in regulation is to control expression of defined genes. For their role in development, they modulate chromatin structure recruiting epigenetic modification proteins to defined sites of the genome. Examples of this function are HOTAIR, Xist and Kcnqot1. HOTAIR is involved in limb formation and cancer meanwhile Kcnqot1 is involved with the imprinting of its loci.

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Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs

Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here a team led by researchers from the NYU School of Medicine investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemia (T-ALL). By ...

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