Tag Archives: colorectal tumorigenesis

lncRNA ASBEL-TCF3 complex is required for the tumorigenicity of colorectal cancer cells

Wnt/β-catenin signaling plays a key role in the tumorigenicity of colon cancer. Furthermore, it has been reported that lncRNAs are dysregulated in several steps of cancer development. Here researchers from the University of Tokyo show that β-catenin directly activates the transcription of the long noncoding RNA (lncRNA) ASBEL [antisense ncRNA in the ANA (Abundant in neuroepithelium area)/BTG3 (B-cell translocation gene ...

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