Tag Archives: central nervous system

During both development and adulthood, the human brain expresses many thousands of long noncoding RNAs (lncRNAs), and aberrant lncRNA expression has been associated with a wide range of neurological diseases. Although the biological significance of most lncRNAs remains to be discovered, it is now clear that certain lncRNAs carry out important functions in neurodevelopment, neural cell function, and perhaps even ...

The development of the central nervous system (CNS) is a complex orchestration of stem cells, transcription factors, growth/differentiation factors, and epigenetic control. Noncoding RNAs have been identified, classified, and studied for their functional roles in many systems including the CNS. In particular, the class of long noncoding RNAs (lncRNAs) has generated both enthusiasm and skepticism due to the unexpected discovery, ...

Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, researchers from the University of Oxford describe the genomically local and more distal functions of Paupar, a vertebrate-conserved and central nervous system-expressed ...

Long non-coding RNAs (LncRNAs) have emerged recently as major players in governing fundamental biological processes. More than half of all known LncRNAs are expressed in the central nervous systems in mammals, and are found in different neuron types. The aberrant expression of LncRNAs has been associated with neurological disorders, such as Alzheimer’s. Since 2009, Arraystar has engineered microarrays for assessing ...

The central nervous system (CNS) is a complex biological system composed of numerous cell types working in concert. The intricate development and functioning of this highly ordered structure depends upon exquisite spatial and temporal control of gene expression in the cells comprising the CNS. Thus, gene regulatory networks that control cell fates and functions play critical roles in the CNS. ...