Tag Archives: cardiac

Document Type and Number: United States Patent Application 20160312283 Abstract: This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention. Inventors: Ounzain, Samir ...

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate gene expression; however, their mechanisms of action remain poorly understood. Here, MIT researchers experimentally determine the secondary structure of Braveheart (Bvht) using chemical probing methods and show that this ∼590 nt transcript has a modular fold. Using CRISPR/Cas9-mediated editing of mouse embryonic stem cells, they find that ...

from Genetic Engineering News – Researchers at  MIT say they have deciphered the structure of one type of long noncoding RNA (lncRNA) and used that information to figure out how it interacts with a cellular protein to control the development of heart muscle cells. This is one of first studies to link the structure of lncRNAs to their function. “Emerging ...

Thierry Pedrazzini, Experimental Cardiology Unit Department of Medicine University of Lausanne Medical School Lausanne, Lausanne, SWITZERLAND speaks on “Importance of long noncoding RNAs in cardiac homeostasis”. This seminar has been recorded by ICGEB