Tag Archives: cancer

The central dogma of molecular biology posits that genes are transcribed into messenger RNA (mRNA), which is then translated into proteins, which, in turn, are ultimately responsible for all cellular functions. Yet recent research has revealed that RNAs that do not encode proteins — known as noncoding RNAs — play important roles in normal physiological processes and can contribute to ...

Join Exiqon on Thursday 9 June and hear the authors of two new high impact papers in Nature and Science Translational Medicine describe how long non-coding RNAs are providing new therapeutic avenues in cancer and heart disease. Prof. Jean-Christophe Marine from K.U. Leuven in Belgium will present results from the recent Nature paper showing that melanoma cancer cells are addicted ...

Some lncRNAs associated with cancers. The colour represents either upregulated (red) or downregulated (blue) compared to normal tissues Large-scale cDNA sequencing projects, together with technological advancements such as tiling arrays and the next generation RNA sequencing provided an unprecedented view of the transcriptome complexity. Surprisingly, only 1–2 % of the whole genome encodes proteins, with evidence of at least 80 % of ...

As a result of the explosion of large-scale genome sequencing projects, we have gained great insights into the evolution of complex organisms. Perhaps, one of the most unexpected outcomes of these studies was that the human genome contains only about 20,000 protein-coding genes, which occupy less than 3% of human DNA. Most of these genes also appear rather well conserved ...

Uveal melanoma (UM) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with UM develop metastases after diagnosis. Long non-coding RNAs (lncRNAs) are involved in both oncogenic and tumour suppression pathways. Researchers at Shanghai JiaoTong University School of Medicine show that lncRNA PAUPAR is present at low levels in UM tissues ...

Malignant tumors are harmful to human health and have become a leading cause of mortality worldwide. According to the “global cancer report 2012” released by the World Health Organization (WHO), the global incidence of cancer is rapidly increasing. Early diagnosis and treatment are critical for the research and clinical treatment of tumors. Furthermore, tumor molecular markers are of great practical ...

 Increased expression of SLNCR1 is associated with reduced overall melanoma survival  SLNCR1 knockdown decreases melanoma invasion  The transcription factors AR and Brn3a bind adjacent sequences in SLNCR1  SLNCR1, AR, and Brn3a are all required for upregulating the matrix metalloproteinase MMP9 Long non-coding RNAs (lncRNAs) have been implicated in numerous physiological processes and diseases, most notably cancers. However, little is known ...

Long non-coding RNA and mRNAs are long RNAs (> 200 nucleotides) compared to microRNAs. In blood, long RNAs may be protected by serum extracellular vesicles, such as apoptotic bodies (ABs), microvesicles (MVs), and exosomes (EXOs). They are potential biomarkers for identifying cancer. Sera from 76 pre-operative CRC patients, 76 age- and sex-matched healthy subjects and 20 colorectal adenoma (CA) patients ...

Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis of different types of ...

Lung cancer is the leading cause of cancer death around the world. The advanced discovery of numerous long noncoding RNAs (lncRNAs) has dramatically changed the understanding of biology of human cancers, including lung cancer. LncRNAs are a group of noncoding RNAs (ncRNAs) with a length greater than 200 nucleotides with limited or no protein-coding capacity. Increasing evidence has shown that ...