Tag Archives: cancer

Decoding critical long non-coding RNA in ovarian cancer

lncrna

Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 alone. This high mortality is primarily caused by resistance to therapy and the diagnosis of ovarian cancer after it has already metastasized, which occurs in approximately 80 percent of patients. A new study from Sidney Kimmel ...

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University of Newcastle lands $675K to study lncRNA

lncRNA

In total, the University of Newcastle (UON) has attracted $12.2m in the latest round of National Health and Medical Research Council (NHMRC) funding to investigate some of the nation’s and world’s greatest health challenges. Senior Deputy Vice-Chancellor (Research and Innovation), Professor Kevin Hall, said the NHMRC’s support for Newcastle’s researchers was testament to the University’s reputation for conducting world-class research. ...

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The Dark Side of the Epitranscriptome – Chemical Modifications in Long Non-Coding RNAs

lncrna

The broad application of next-generation sequencing technologies in conjunction with improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in terms of quantity and variety. In humans, 70-90% of the genome is transcribed, but only ~2% carries the blueprint for proteins. Hence, there is a huge class of non-translated transcripts, called long non-coding RNAs (lncRNAs), which have ...

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Post-doc Position Available – Biological and Biomedical Sciences

lncRNA

Date Posted – Oct. 17, 201 Department – Biological and Biomedical Sciences Department Website – http://www.nccu.edu/academics/sc/artsandsciences/bio… Institution – North Carolina Central University Amazing Postdoctoral Position Available in Breast Cancer Health Disparities Research Research project involves the characterization and study of molecules associated with cancer health disparities, pseudogenes/lncRNA, lipid signaling, and cholesterol/triglyceride metabolism. The overall goal of the laboratory is to characterize the role of ...

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Featured lncRNA Job – Biomedical Scientist

lncRNA

Date Posted 08/14/2017 Open Until Filled No Anticipated Application Deadline (Close date) 10/29/2017 Working Title Biomedical Scientist Job Classification Research Scientist Department Name 33203-Pharm-Pharmaceutical Science Job Type Research Associate Position Number 0135404 Hiring Range TBD based on qualifications Position Description Dr. Da Yang’s laboratory at the University of Pittsburgh is seeking a highly motivated and organized Biomedical Scientist to join ...

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The diagnostic/prognostic potential and molecular functions of long non-coding RNAs in the exosomes

lncrna

Cholangiocarcinoma (CCA) is an aggressive malignancy associated with unfavorable prognosis, and it’s difficult to diagnose and no effective treatments are available. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and metastasis. Intact lncRNAs from exosomes have sparked much interest as potential biomarker for the non-invasive analysis of disease. Here, via exosome sequencing on lncRNAs, GO analysis, KEGG pathway and ...

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lncRNA NEAT1 as a prognostic factor for survival of cancer

lncrna

Researchers at the Affiliated Hospital of Qingdao University conducted a meta-analysis to analyze available data to identify the prognostic role of NEAT1 in multiple carcinomas. A total of 12 studies with 3,262 cancer patients were pooled in the analysis to evaluate the prognostic value of NEAT1 in multiple tumors. High expression levels of NEAT1 were demonstrated to be associated with ...

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The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer development and progression, including the metastatic spread of disease. Through in silico and biological analyses, investigators at Case Western Reserve University identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive breast cancer phenotypes, as well as with metastatic competence and disease recurrence in multiple clinical cohorts. ...

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The role of a new class of long noncoding RNAs transcribed from ultraconserved regions in cancer

lncRNA

Ultraconserved regions (UCRs) represent a relatively new class of non-coding genomic sequences highly conserved between human, rat and mouse genomes. These regions can reside within exons of protein-coding genes, despite the vast majority of them localizes within introns or intergenic regions. Several studies have undoubtedly demonstrated that most of these regions are actively transcribed in normal cells/tissues, where they contribute ...

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