Tag Archives: biomarkers

Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma

lncRNA

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

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The Future of Biomarkers and Genomics

lncrna

from UroToday.com by  Zachary Klaassen, – Professor Manfred Wirth from Germany provided an update on the future of biomarkers and genomics at this afternoon’s EAU Update in Prostate Cancer in Vienna, Austria. Dr. Wirth divided his presentation into three subsections: Why are biomarkers needed for prostate cancer? There are several reasons according to Dr. Wirth why biomarkers are needed for prostate cancer, ...

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lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia

lncrna

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy with great variability of prognostic behaviors. Previous studies have reported that long non-coding RNAs (lncRNAs) play an important role in AML and may thus be used as potential prognostic biomarkers. However, thus use of lncRNAs as prognostic biomarkers in AML and their detailed mechanisms of action in this disease have ...

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Three-lncRNA signature – a novel biomarker for the accurate prognosis prediction HNSCC

lncRNA

Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial ...

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Long intergenic non-coding RNA expression signature in human breast cancer

lncrna

Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. Researchers at the Vanderbilt University Medical Center designed a two-stage study, including 1,000 breast tumor RNA-seq data from The ...

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Circulating lncRNA levels too low to serve as biomarkers

lncRNA

Long non-coding RNAs (lncRNA) are a new class of regulatory molecules with diverse cellular functions. Recent reports have suggested that extracellular lncRNAs are detectable in human plasma and may serve as biomarkers. Here, researchers at the Ottawa Hospital Research Institute sought to investigate circulating lncRNAs as potential biomarkers for pulmonary arterial hypertension (PAH). Eighty-four lncRNAs, representing some of the most ...

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Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma

Previous studies revealed that circulating (either from plasma or serum) long non-coding RNA may predict the occurrence or prognosis of multiple human malignant tumors. In this study, researchers from Nanjing Medical University mainly explored whether circulating lncRNAs can be utilized as biomarkers predicting the development of human esophageal squamous cell carcinoma (ESCC). LncRNA microarray was applied to screen the potential ...

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Featured lncRNA Job – Role of Non-coding RNAs in Cancer

lncRNA

The Departments of Biomedical Informatics, Systems Biology and Medicine at Columbia University  in NY are seeking a highly motivated Research Associate to join the laboratories of Drs. Raul Rabadan and Kenneth Olive to study the role of non-coding RNAs in cancer. The successful candidate will join an interdisciplinary team of researchers with expertise in computational and experimental biology. We are ...

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Dysregulation of long non-coding RNA in breast cancer

lncRNA

Long non-coding RNAs (lncRNAs), which occupy nearly 98% of genome, have crucial roles in cancer development, including breast cancer. Breast cancer is a disease with high incidence. Despite of recent progress in understanding the molecular mechanisms and combined therapy strategies, the functions and mechanisms of lncRNAs in breast cancer remains unclear. Researchers from Zhejiang University review the currently basic knowledge ...

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Identification of long non-coding RNAs biomarkers for early diagnosis of myocardial infarction

lncRNA

Long non-coding RNAs (lncRNAs) have recently been shown as novel promising diagnostic or prognostic biomarkers for various cancers. However, lncRNA expression patterns and their predictive value in early diagnosis of myocardial infarction (MI) have not been systematically investigated. In this study, researchers from Harbin Medical University performed a comprehensive analysis of lncRNA expression profiles in MI and found altered lncRNA ...

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