Tag Archives: biomarkers

Long non-coding RNAs in ischemic stroke

lncRNA

Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using ...

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lncRNA gene signatures for prediction of breast cancer intrinsic subtypes and prognosis

lncRNA

Breast cancer is intrinsically heterogeneous and is commonly classified into four main subtypes associated with distinct biological features and clinical outcomes. However, currently available data resources and methods are limited in identifying molecular subtyping on protein-coding genes, and little is known about the roles of long non-coding RNAs (lncRNAs), which occupies 98% of the whole genome. lncRNAs may also play ...

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Circulating lncRNAs Serve as Diagnostic Markers for Hepatocellular Carcinoma

lncRNA

Circulating (serous or plasmic) long non-coding RNA (lncRNA) as biomarkers for predicting the diagnosis or prognosis of human disease have been well documented. Due to the sensibility or specificity limitation of Alpha Fetoprotein (AFP), a cluster lncRNAs were revealed as fingerprints for hepatocellular carcinoma (HCC). In this study, researchers at Huai’an First People’s Hospital enrolled all the reported circulating lncRNAs ...

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Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma

lncRNA

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

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The Future of Biomarkers and Genomics

lncrna

from UroToday.com by  Zachary Klaassen, – Professor Manfred Wirth from Germany provided an update on the future of biomarkers and genomics at this afternoon’s EAU Update in Prostate Cancer in Vienna, Austria. Dr. Wirth divided his presentation into three subsections: Why are biomarkers needed for prostate cancer? There are several reasons according to Dr. Wirth why biomarkers are needed for prostate cancer, ...

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lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia

lncrna

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy with great variability of prognostic behaviors. Previous studies have reported that long non-coding RNAs (lncRNAs) play an important role in AML and may thus be used as potential prognostic biomarkers. However, thus use of lncRNAs as prognostic biomarkers in AML and their detailed mechanisms of action in this disease have ...

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Three-lncRNA signature – a novel biomarker for the accurate prognosis prediction HNSCC

lncRNA

Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial ...

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Long intergenic non-coding RNA expression signature in human breast cancer

lncrna

Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several clinicopathological variables including receptor status and patient survival. Researchers at the Vanderbilt University Medical Center designed a two-stage study, including 1,000 breast tumor RNA-seq data from The ...

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Circulating lncRNA levels too low to serve as biomarkers

lncRNA

Long non-coding RNAs (lncRNA) are a new class of regulatory molecules with diverse cellular functions. Recent reports have suggested that extracellular lncRNAs are detectable in human plasma and may serve as biomarkers. Here, researchers at the Ottawa Hospital Research Institute sought to investigate circulating lncRNAs as potential biomarkers for pulmonary arterial hypertension (PAH). Eighty-four lncRNAs, representing some of the most ...

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