Tag Archives: bioinformatics

Post-doc Positions Available – Bioinformatics and Cancer Cell Biology

lncRNA

Job Description Postdoctoral Associate positions (Bioinformatics and Cancer Cell Biology) are available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in our laboratory at Sanford-Burnham Medical Discovery Institute, Orlando FL USA.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified ( Lee et al Science Advances 2017 3(5): e1602505, Mazar et al Mol. Cell. Biol. ...

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Postdoc position available – discovery and characterization of novel long non-coding RNAs

lncRNA

Position Summary: A postdoctoral scholar position in the area of Computational Biology/Bioinformatics is available in the laboratory of Dr. Christopher Maher at The McDonnell Genome Institute at Washington University School of Medicine in St. Louis. Our lab focuses on developing computational methods for analyzing large-scale cancer genomics data collections from solid tumors to improve our understanding of cancer biology and ...

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Post-doc Position Available: Bioinformatics of lncRNA in Cardiac Regeneration

lncrna

The “Genomics of Long Non-Coding RNAs in Disease” Laboratory at the University of Bern has an opportunity for a Bioinformatics Postdoc. Diseases of the heart are the single greatest cause of death worldwide. Future regenerative therapies depend on understanding the molecular pathways underlying the development and differentiation of heart cells. We are excited about the role of lncRNAs in these ...

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Identification and validation long non-coding RNAs of oral squamous cell carcinoma by bioinformatics method

lncRNA

Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, researchers from the Children Hospital of Chongqing Medical University used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. First, they downloaded datasets of OSCC from National Center ...

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DES-ncRNA – A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining

lncRNA

Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding ...

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Next-Generation Sequencing Analysis of Long Noncoding RNAs

lncRNA

Next-generation sequencing approaches, in particular RNA-seq, provide a genome-wide expression profiling allowing the identification of novel and rare transcripts such as long noncoding RNAs (lncRNA). Many RNA-seq studies have now been performed aimed at the characterization of lncRNAs and their possible involvement in cell development and differentiation in different organisms, cell types, and tissues. Researchers from the National Institute of ...

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RNA-Seq analysis of lncRNAs

RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA molecules originating from a genome at a given moment in time. In recent years, the advent of RNA-Seq has facilitated genome-wide expression profiling, including the identification of novel and rare transcripts like noncoding RNAs and novel alternative splicing isoforms. Advances in transcriptome reconstruction ...

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LncVar – a database of genetic variation associated with long noncoding genes

Long noncoding RNAs (lncRNAs) are essential in many molecular pathways, and are frequently associated with disease, but the mechanisms of most lncRNAs have not yet been characterized. Genetic variations, including SNPs and structural variations, are widely distributed in the genome, including lncRNA gene regions. As the number of studies on lncRNAs grows rapidly, it is necessary to evaluate the effects ...

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Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs

lncRNA

Although a considerable portion of eukaryotic genomes is transcribed as long noncoding RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding catalogue of mechanistically investigated lncRNAs has provided evidence for distinct functional subclasses, which are now ripe for exploitation as a general model to predict functions for uncharacterised lncRNAs. By utilising publicly-available genome-wide datasets and computational methods, researchers ...

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Long non-coding RNA – computational models

lncRNA

LncRNAs have attracted lots of attentions from researchers worldwide in recent decades. With the rapid advances in both experimental technology and computational prediction algorithm, thousands of lncRNA have been identified in eukaryotic organisms ranging from nematodes to humans in the past few years. More and more research evidences have indicated that lncRNAs are involved in almost the whole life cycle ...

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