by a News Reporter-Staff News Editor at Life Science Weekly
Researchers detail new data in Membrane Proteins. According to news reporting out of Iksan, South Korea, by NewsRx editors, research stated,
Non-coding RNAs have been less studied in cartilage development and destruction regulated by sophisticated molecular events despite their considerable theranostic potential. In this study, we identified significant down-regulation of mR-101 and up-regulation of lncRNA, HOITIP in the processes of endochondral ossification and osteoarthritic progression.
Our news journalists obtained a quote from the research from Wonkwang University,
In wing mesenchymal cells, up-expression of miR-101 by TGF-beta 3 treatment is targeting DNMT-3B and thereby altered the methylation of integrin-alpha 1 addressed as a positive regulator of endochondral ossification in this study. In like manner, down-regulation of miR-101 also coordinately up-regulated DNMT-3B, down-regulated integrin-alpha 1, and resulted in cartilage destruction. In an OA animal model, introduction of lenti-viruses that encoded miR-101 or integrin-alpha 1 successfully reduced cartilage destruction. In like manner, long non-coding RNA (lncRNA), HOITIP, a known regulator for HoxA genes, was highly up-regulated and concurrent down-regulation of HoxA13 displayed the suppression of integrin-alpha 1 in OA chondrocytes.
According to the news editors, the research concluded: “Two non-coding RNAs, miR-101 and HOTTIP regulate cartilage development and destruction by modulating integrin-alpha 1 either epigenetically by DNMT-3B or transcriptionally by HoxA13 and data further suggest that these non-coding RNAs could be a potent predictive biomarker for OA as well as a therapeutic target for preventing cartilage-related diseases.”
For more information on this research see: Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-alpha 1. Cellular Signalling, 2013;25(12):2878-2887. Cellular Signalling can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier – www.elsevier.com; Cellular Signalling – www.elsevier.com/wps/product/cws_home/525462)
Our news journalists report that additional information may be obtained by contacting D. Kim, Wonkwang Univ, Sch Med, Dept. of Orthoped Surg, Iksan 570749, Chunbuk, South Korea. Additional authors for this research include J. Song, J. Han, Y. Kim, C.H. Chun and E.J. Jin (see also Membrane Proteins).