Search Results for: long non coding rna review

Review – Posttranscriptional Gene Regulation by Long Non-coding RNA

graphical_abstract

Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. For example, through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease.

  • Yoon JH, Abdelmohsen K, Gorospe M. (2012) Posttranscriptional Gene Regulation by Long Noncoding RNA.  J Mol Biol [Epub ahead of print]. [abstract]

Incoming search terms:

  • lncrna review
  • lncrna splicing

The functional role of long non-coding RNAs and epigenetics

Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review focuses on the functional roles of lncRNAs in epigenetics and related research progress are summarized.

lncRNA

  • Cao J. (2014) The functional role of long non-coding RNAs and epigenetics. Biol Proced Online 16:11. [article]

Long non-coding RNAs in cancer: implications for personalized therapy

lncRNA

Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, the authors briefly:

  1. Introduce these three classes of long non-coding RNAs.
  2. Discuss their applications as diagnostic and prognostic biomarkers.
  3. Describe their appeal as targets and as drugs,
  4. Point out the limitations that still lie ahead of their definitive entry into clinical practice.
  • Vitiello M, Tuccoli A, Poliseno L. (2014) Long non-coding RNAs in cancer: implications for personalized therapy. Cell Oncol (Dordr) [Epub ahead of print]. [abstract]

Crop improvement and resistance to pathogens benefits from non-coding RNA studies

lncRNA

With the rise of emerging economies around the world and a concomitant upgrade of health care systems, the global population has been rapidly expanding. As a consequence, worldwide demand for agricultural products is also growing.

Crops now provide food and the other important resources for seven billion humans.

Food supplies are primarily based on such crops as wheat, maize, rice and vegetables. But as the area of arable land and of cultivated land continues to decline, the future ability to meet the world’s food security needs has come under a cloud of uncertainty.

Meanwhile, the use of pesticides and fertilizers has triggered long-term adverse effects on the environment, and has presented a serious threat to human health.

Incoming search terms:

  • dna non examples
  • is lncRNA gene
  • non examples of nucleic acids
  • nonexamples for gene
  • plasmid protein coding area

Long non-coding RNAs in cancer: implications for personalized therapy

Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, the authors briefly introduce these three classes of long non-coding RNAs. We then discuss their applications as diagnostic and prognostic biomarkers. Finally, we describe their appeal as targets and as drugs, while pointing out the limitations that still lie ahead of their definitive entry into clinical practice.

lncRNA

  • Vitiello M, Tuccoli A, Poliseno L. (2014) Long non-coding RNAs in cancer: implications for personalized therapy. Cell Oncol (Dordr). [Epub ahead of print]. [abstract]