Search Results for: long non coding rna review
Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. For example, through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease.
- Yoon JH, Abdelmohsen K, Gorospe M. (2012) Posttranscriptional Gene Regulation by Long Noncoding RNA. J Mol Biol [Epub ahead of print]. [abstract]
Incoming search terms:
- lncrna review
- lncrna splicing
- gene regulation in eukaryotes
- long noncoding RNA review
- regulation of the eukaryotic transcription
- gene regulation review
- gene regulation review paper
- Long non-coding RNAs: insights into functions
- transcriptional regulation review
The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, the authors review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight kinds of distinct modes of action for sncRNAs and lncRNAs respectively, by which functional ncRNAs mediate the regulation of intracellular events.
- Huang B1, Zhang R. (2014) Regulatory non-coding RNAs: revolutionizing the RNA world. Mol Biol Rep [Epub ahead of print]. [abstract]
The differentiation and activation of both innate and adaptive immune cells is highly dependent on a coordinated set of transcriptional and post-transcriptional events. Chromatin-modifiers and transcription factors regulate the accessibility and transcription of immune genes, respectively. Immune cells also express miRNA and RNA-binding proteins that provide an additional layer of regulation at the mRNA level. However, long noncoding RNAs (lncRNAs), which have been primarily studied in the context of genomic imprinting, cancer, and cell differentiation, are now emerging as important regulators of immune cell differentiation and activation. In this review, the authors provide a brief overview of lncRNAs, their known functions in immunity, and discuss their potential to be more broadly involved in other aspects of the immune response.
- Fitzgerald KA, Caffrey DR. (2014) Long noncoding RNAs in innate and adaptive immunity. Curr Opin Immunol 26C, 140-146. [abstract]
Incoming search terms:
- human adaptive rna immunity
Post Doctoral Scientist for studying Long non-coding RNA (lncRNA) biology in Cardiovascular Development and Regeneration
Posted: January 14, 2014
Expires: February 28, 2014
Requisition number: LncRNA, Cardiovascular development, Stem cells, Development, RNA biology, Regeneration
Science jobs from University of Cologne:
Incoming search terms:
- leo kurian cologne nature job
- leo kurian cologne nature jobs
- lncrna mechanism
Long non-coding RNAs (lncRNAs) interact with the nuclear architecture and are involved in fundamental biological mechanisms, such as imprinting, histone-code regulation, gene activation, gene repression, lineage determination, and cell proliferation, all by regulating gene expression. Understanding the lncRNA regulation of transcriptional or post-transcriptional gene regulation expands our knowledge of disease. Several associations between altered lncRNA function and gene expression have been linked to clinical disease phenotypes. Early advances have been made in developing lncRNAs as biomarkers. Several mouse models reveal that human lncRNAs have very diverse functions. Their involvement in gene and genome regulation as well as disease underscores the importance of lncRNA-mediated regulatory networks. Because of their tissue-specific expression potential, their function as activators or repressors, and their selective targeting of genes, lncRNAs are of potential therapeutic interest. The authors review the regulatory mechanisms of lncRNAs, their major functional principles, and discuss their role in Mendelian disorders, cancer, cardiovascular disease, and neurological disorders.
- Maass PG, Luft FC, Bähring S. (2014) Long non-coding RNA in health and disease. J Mol Med (Berl) [Epub ahead of print]. [abstract]