Search Results for: incrna

Everything old is new again: (linc)RNAs make proteins!

lncRNA

Conventional protein-coding genes account for only a fraction of the RNA transcribed in animal genomes. Many of us grew up thinking that RNAs came in two flavours: those with protein-coding capacity and non-coding RNAs with structural roles, in the form of ribosomal RNAs, tRNAs, snoRNAs, etc. Interest in other forms of long non-coding RNAs (lincRNAs) has been growing over the ...

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The four dimensions of noncoding RNA conservation

Evolutionary conservation is widely used as an indicator of the functional significance of newly discovered genes. Although the simple search for homology at the nucleotide or amino acid sequence level has proven to be valuable for protein-coding genes, these criteria are too narrow to describe fully the selection process for long noncoding RNAs (lncRNAs). LncRNA conservation includes four dimensions: the ...

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Investigation of Circulating LncRNAs in B-cell Neoplasms

Long non-coding RNAs (lncRNA) which are longer than 200 base pairs in length, play important role in the cellular machinery. Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are neoplasms of B-cells. Researchers at Istanbul University aimed to investigate circulating lncRNA levels of CLL and MM patients. For this purpose they selected 5 candidate lncRNAs (TUG1, LincRNA-p21, MALAT1, HOTAIR, and ...

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Systematically profiling and annotating long intergenic non-coding RNAs

While more and more long intergenic non-coding RNAs (lincRNAs) were identified to take important roles in both maintaining pluripotency and regulating differentiation, how these lincRNAs may define and drive cell fate decisions on a global scale are still mostly elusive. Systematical profiling and comprehensive annotation of embryonic stem cells lincRNAs may not only bring a clearer big picture of these ...

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lncRNAMap: A map of putative regulatory functions in the long non-coding transcriptome

lncRNA

lncRNAMap is an integrated and comprehensive database relating to exploration of the putative regulatory functions of human lncRNAs with two mechanisms of regulation, by encoding siRNAs and by acting as miRNA decoys. To investigate lncRNAs producing siRNAs that regulate protein-coding genes, lncRNAMap integrated small RNAs (sRNAs) that were supported by publicly available deep sequencing data from various sRNA libraries and ...

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Long non-coding RNA UCA1 promotes breast tumor growth

lncRNA

Functional genomics studies have led to the discovery of a large amount of non-coding RNAs from the human genome; among them are long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs could have a critical role in the regulation of cellular processes such as cell growth and apoptosis as well as cancer progression and metastasis. As master gene regulators, lncRNAs ...

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Featured long noncoding RNA – THRIL

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, researchers from the Sanford-Burnham Medical Research Institute used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was found to be differentially ...

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Knockout Mice Study: Long Noncoding RNAs "Play Central Roles in Mammalian Development and Physiology"

lncRNA

by Casey Luskin at Evolution News & Views A few years ago I wrote about challenges to the claim that “junk DNA” wasn’t necessary for development. In experiments with mice, researchers had supposedly “knocked out” non-coding DNA, yet the mice themselves as they grew turned out to be healthy. Now a new study in eLife, “Multiple knockout mouse models reveal ...

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A Computational Framework to Infer Human Disease-Associated Long Noncoding RNAs

lncRNA

As a major class of noncoding RNAs, long noncoding RNAs (lncRNAs) have been implicated in various critical biological processes. Accumulating researches have linked dysregulations and mutations of lncRNAs to a variety of human disorders and diseases. However, to date, only a few human lncRNAs have been associated with diseases. Therefore, it is very important to develop a computational method to ...

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The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL

lncRNA

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, a team led by researchers at the Sanford-Burnham Medical Research Institute used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was ...

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