Search Results for: incrna

Knockout Mice Study: Long Noncoding RNAs "Play Central Roles in Mammalian Development and Physiology"

lncRNA

by Casey Luskin at Evolution News & Views A few years ago I wrote about challenges to the claim that “junk DNA” wasn’t necessary for development. In experiments with mice, researchers had supposedly “knocked out” non-coding DNA, yet the mice themselves as they grew turned out to be healthy. Now a new study in eLife, “Multiple knockout mouse models reveal ...

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A Computational Framework to Infer Human Disease-Associated Long Noncoding RNAs

lncRNA

As a major class of noncoding RNAs, long noncoding RNAs (lncRNAs) have been implicated in various critical biological processes. Accumulating researches have linked dysregulations and mutations of lncRNAs to a variety of human disorders and diseases. However, to date, only a few human lncRNAs have been associated with diseases. Therefore, it is very important to develop a computational method to ...

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The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL

lncRNA

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, a team led by researchers at the Sanford-Burnham Medical Research Institute used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was ...

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Junking the idea of junk

from The Economist A newly recognised class of genes really does matter GENETICS often progresses by breaking things. Early experiments used naturally broken genes—mutations—to work out the basic rules. Then geneticists found out how to induce mutations with radiation and chemicals. That gave them more material to work with, but the mutations still appeared at random. Then the “knockout mouse” ...

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Regulatory roles played by long intergenic noncoding RNA in three types of cancer

from Biology Computes Ying Sha, Sanjeev Sariya, Ali M Pirani, Adrian Lawsin BACKGROUND Cancer is a disease of aberrant gene expression.  Genome-wide association studies in cancer reveal that more than 80% of cancer-associated SNPs (single-nucleotide polymorphism) occur in noncoding regions of the genome.  Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides.  This arbitrary limit distinguishes lncRNAs from miRNAs (microRNA), piRNAs (piwi-interacting ...

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The vast, conserved mammalian lincRNome

lncRNA

Genome analysis of humans and other mammals reveals a surprisingly small number of protein-coding genes, only slightly over 20,000 (although the diversity of actual proteins is substantially augmented by alternative transcription and alternative splicing). Recent analysis of the mammalian genomes and transcriptomes, in particular, using the RNA-seq technology, shows that, in addition to protein-coding genes, mammalian genomes encode many long ...

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Systematically profiling and annotating long intergenic non-coding RNAs in human embryonic stem cell

lncRNA

While more and more long intergenic non-coding RNAs (lincRNAs) were identified to take important roles in both maintaining pluripotency and regulating differentiation, how these lincRNAs may define and drive cell fate decisions on a global scale are still mostly elusive. Systematical profiling and comprehensive annotation of embryonic stem cells lincRNAs may not only bring a clearer big picture of these ...

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Lnc-ing p53 and epigenetic silencing via a novel noncoding RNA

from Biome It is now well-established that noncoding regions of the genome have a vital role to play in gene expression. Genome-wide approaches have led to the identification of an abundance of noncoding RNAs, from microRNAs to long non-coding RNAs (lncRNAs). LncRNAs were initially discovered in the 1980’s but the extent of their transcription was only realized over twenty years ...

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Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here researchers at the National Institutes of Health identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Their analysis revealed highly dynamic ...

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Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

Long intergenic noncoding RNAs (lincRNAs) have been shown to be novel regulators for both transcription and posttranscriptional/translation. One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts. However, the impact of such regulation on colorectal cancer (CRC) remains to be determined. Now, researchers at the Stony Brook University have discovered that the expression level ...

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