Search Results for: incrna

lincRNAs linked to increased children’s risk of blood infection

lncRNA

A team led by Oxford University has identified genes that make certain children more susceptible to invasive bacterial infections by performing a large genome-wide association study in African children. Bacteraemia, bacterial infection of the bloodstream, is a major cause of illness and death in sub-Saharan Africa but little is known about whether human genetics play a part. The leading bacterial ...

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Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures

Inappropriate transcriptional activation of innate immunity is a pathological feature of several cardiometabolic disorders, but little is known about inflammatory modulation of long intergenic noncoding RNAs (lincRNAs) in disease-relevant human tissues. Researchers at the University of Pennsylvania applied deep RNA sequencing (>500 million filtered reads per sample) to blood and adipose during low-dose experimental endotoxemia (lipopolysaccharide) in a healthy human, ...

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lincRNAs are required for life

lncRNA

Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, a team led by researchers at Harvard University have developed a collection of 18 lncRNA knockout strains in which the locus is maintained transcriptionally ...

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Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis

lncRNA

Skeletal muscle differentiation is orchestrated by a network of transcription factors, epigenetic regulators, and non-coding RNAs. The transcription factor Yin Yang 1 (YY1) silences multiple target genes in myoblasts (MBs) by recruiting Ezh2 (Enhancer of Zeste Homologue2). To elucidate genome-wide YY1 binding in MBs, we performed chromatin immunoprecipitation (ChIP)-seq and found 1820 specific binding sites in MBs with a large ...

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Featured Long Non-coding RNA – lincRNA-Cox2

lincRNA

An inducible program of inflammatory gene expression is central to antimicrobial defenses. Signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin modifying factors collaborate to control this response. Here, researchers from University of Massachusetts Medical School identify a long noncoding RNA that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce ...

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vlincRNAs: very long intergenic non-coding RNAs

lncRNAs

The function of the non-coding portion of the human genome remains one of the most important questions of our time. Its vast complexity is exemplified by the recent identification of an unusual and notable component of the transcriptome – very long intergenic non-coding RNAs, termed vlincRNAs. Here a team led by researchers from the St. Laurent Institute identify 2,147 vlincRNAs ...

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CMU Prof receives Kaufman Grant for research on "High-Throughput Probing of Human IncRNA Structure"

Press Release: Six Carnegie Mellon Professors Awarded Research Grants From Pittsburgh Foundation’s Charles E. Kaufman Fund Contacts: Ken Walters / 412-268-1151 / walters1@andrew.cmu.edu Chriss Swaney / 412-268-5776 / swaney@andrew.cmu.edu PITTSBURGH—Six Carnegie Mellon University professors are among the first series of grant recipients of The Charles E. Kaufman Foundation, part of The Pittsburgh Foundation, which today announced nearly $1.6 million in ...

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