Search Results for: gomafu

Featured long non-coding RNA – Gomafu

Gomafu

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, researchers from the University of Queensland, Australia profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically ...

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Splicing regulation by long noncoding RNAs

lncRNA

Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs ...

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Hidden gene could help control anxiety

lncRNA

A new study has found the mechanism used by a hidden gene to affect how the brain responds to stressful experiences, in a discovery that could eventually help control anxiety. University of Queensland scientists, together with colleagues at the University of California Irvine and the Garvan Institute of Medical Research, discovered that Gomafu, a gene recently associated with schizophrenia, causes ...

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No longer junk: Role of long noncoding RNAs in autism risk

lncRNA

by Nikolaos Mellios, Mriganka Sur RNA acts as the intermediary between genes and proteins, but the function of pieces of RNA that do not code for protein has, historically, been less clear. Researchers have ignored these noncoding RNAs until recently for not complying with the central dogma of biology — that a straight line runs from gene to RNA (transcription) ...

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Featured New Product – The SmartChip Human LncRNA1 Panel

The field of lncRNA research is in the midst of a rapid discovery phase, but that doesn’t mean your reagents have to be“experimental”. In collaboration with Biogazelle, we’ve designed SmartChip Human lncRNA-1 Panels to maximize your investigation of lncRNA expression. They contain over 1700 triplicate, predispensed PCR assays that have been extensively validated and annotated. In addition, we’ve ensured that ...

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Low levels of RNA linked to schizophrenia

from the Sydney Morning Herald by Nicky Phillips Australian scientists have described how some neurons in the brain switch off certain genes as part of normal brain function, a process that appeared disturbed in people with schizophrenia. While most people were familiar with the role DNA played instructing the body’s cells to produce proteins, a far greater amount of genetic ...

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