A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. The authors review progress in understanding the biogenesis and regulatory mechanisms of lncRNAs. They describe diverse computational and high throughput technologies for identifying and studying lncRNAs. They discuss the current knowledge of functional elements embedded in lncRNAs as well as insights into the lncRNA-based regulatory network in animals. The authors also describe genome-wide studies of large amount of lncRNAs in plants, as well as knowledge of selected plant lncRNAs with a focus on biotic/abiotic stress-responsive lncRNAs.
- Bai Y, Dai X, Harrison AP, Chen M. (2014) RNA regulatory networks in animals and plants: a long noncoding RNA perspective. Brief Funct Genomics [Epub ahead of print]. [abstract]