Profiling long noncoding RNA of multi-tissue transcriptome enhances porcine noncoding genome annotation

lncRNA

To construct a comprehensive pig noncoding transcriptome and further enhance porcine noncoding genome annotation, researchers at China Agricultural University performed tissue-based long noncoding RNA (lncRNA) profiling. They identified 32,212 nonredundant lncRNA isoforms corresponding to 18,676 lncRNA loci across 34 normal pig tissues using high-throughput sequencing. Furthermore, they globally assessed the potential relationship between these identified lncRNAs and known protein-coding genes via a comprehensive computation-based strategy, developing a genome-wide lncRNA-targeted genome draft for further functional studies on noncoding genes.

Among these lncRNAs, ubiquitously expressed lncRNA appeared at a higher level compared with tissue-specific one. Findings herein provide insight into comprehensive knowledge of porcine noncoding RNAs and further enhance pig noncoding annotation. For ease of accessing the information of the identified lncRNAs, they deposited those with high confidence in the publicly available NONCODE database, providing a valuable resource for facilitating pig noncoding genomic studies.

Zhao P, Zheng X, Feng W, Wang H, Kang H, Ning C, Du H, Yu Y, Li B, Zhao Y, Liu JF. Profiling long noncoding RNA of multi-tissue transcriptome enhances porcine noncoding genome annotation. Epigenomics [Epub ahead of print]. [abstract]

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