Presentation – REGULATION OF CHROMATIN STRUCTURE BY NONCODING RNA

mol&cellbiolDANESH MOAZED: “REGULATION OF CHROMATIN STRUCTURE BY NONCODING RNA” (CELLULAR DYNAMICS RESEARCH TALKS)

Date/Time
Tue, 4/9/2013, 11:45 a.m. – 1 p.m.
Location
Biolabs Lecture Hall 1080, 16 Divinity Ave.
Description
“Regulation of chromatin structure by noncoding RNA”Danesh Moazed, Ph.D.
Professor of Cell Biology, Harvard Medical School
HHMI Investigator
https://moazed.med.harvard.edu/

Abstract: Noncoding RNAs play central roles in the assembly of repressive heterochromatic domains as in inactivation of one of the two X chromosomes in somatic cells of female mammals or in transcriptional silencing of transposons in many eukaryotes. In fission yeast, long noncoding RNAs (lncRNAs), transcribed from pericentromeric DNA repeats, play two major roles in heterochromatin assembly. First, they act as precursors for the generation of short interfering RNA (siRNA) by the RNAi machinery. Second, they act as scaffolds that are targeted by an siRNA-containing complex, which then recruits a histone methyltransferase to initiate heterochromatin formation. My talk will focus on what defines an siRNA-generating locus and what is required for a lncRNA to act as a scaffold for the recruitment of chromatin modifying complexes.

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