Type of employment: Fixed-term employment, up to four years
Extent: 100 %
Location: Institute of Biomedicine, Gothenburg
First day of employment: By agreement
Reference number: PER 2016/266
Institute of Biomedicine is a huge super department with vast interest in several disciplines of biological research. It employs more than 400 people, including 110 PhD students. Insitute of Biomedicine is actively engaged in teaching activities in medicine, pharmacy and dentistry and laboratory technology programmes.
Long Noncoding RNA biology specializing in RNA epigenetics
Specific subject description
More than two-thirds of the human genome is transcribed, generating thousands of long noncoding RNAs (lncRNAs) that currently outnumber the protein coding RNAs. LncRNA, which are more than 200 nucleotides, do not encode any proteins but take part in all ciritical biological functions that have impact on development and differentiation. Mis-expression of lncRNAs leads to tumorigenesis. Though current estimates put annotated lncRNAs number to more than 20,000 but only a handful of them have been functionally characterized.
Over the last decade, we have been working to understand the functional role of long noncoding RNAs in epigenetic regulation of transcription during development and disease. Recently, we characterized lncRNAs that are associated with both active and repressive chromatin compartments and several of them show significant differential expression across multiple cancers. It is not clear about the mechanisms by which both repressive and active chromatin associated lncRNAs regulate gene expression in normal and pathological contexts. The selected candidate will explore the functional connection between chromatin remodelers and lncRNA in regulating gene expression associated with the pathological events.
The qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.
To be eligible for employment as postdoctoral research fellow, applicants must have a PhD or have attained equivalent scientific competence. Priority should be given to candidates who have been awarded a PhD degree or achieved equivalent scientific competence at the very latest seven years before the application deadline.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.
The primary assessment criterion should be scientific skillls. In the assesment of scientific skills, priority should be given to candidates with extensive experience in cell and molecular biology techniques with high quality publications. In addition, candidates with extensive experience in RNA biology will be given preference.
The successful applicant may also be asked to complete an educational training programme within the first year of employment.
Applications must follow the layout of the recommendations of the Sahlgrenska Academy for applications for teaching positions:
Please note in particular that that the following documents must accompany the application (as pdf-files):
– PhD certificate
– A maximum of 10 selected scientific publications that the applicant want to refer to (as pdf-files)
– Other certificates/degrees/diplomas proving the qualifications
The applicant is responsible for ensuring that the application is complete in accordance with the announcemnt and that it will be sent electronically by the application deadline. Complementary documents, such as publications/books should be sent in three copies to the following address:
SE 405 30 GÖTEBORG