Noncoding RNA May Help Treat Heart Disease

New research indicates that long noncoding RNAs (lncRNAs), a class of noncoding RNA larger than 200 nucleotides, may contribute to the development of cardiac hypertrophy (Viereck J et al. Sci Transl Med. 2016;8[326]:326ra2).

After generating a whole-genome lncRNA profile to identify differentially expressed lncRNAs in heart muscle cells in a mouse model for pressure overload–induced cardiac hypertrophy and heart failure, investigators led by researchers at Hannover Medical School in Germany found that a particular lncRNA that they named cardiac hypertrophy–associated transcript (Chast) was up-regulated.

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Viereck J et al. (2016) Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med 8(326):326ra22. [abstract]

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