Long non-coding RNAs in cancer: implications for personalized therapy

Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, the authors briefly:

  1. Introduce these three classes of long non-coding RNAs.
  2. Discuss their applications as diagnostic and prognostic biomarkers.
  3. Describe their appeal as targets and as drugs,
  4. Point out the limitations that still lie ahead of their definitive entry into clinical practice.
  • Vitiello M, Tuccoli A, Poliseno L. (2014) Long non-coding RNAs in cancer: implications for personalized therapy. Cell Oncol (Dordr) [Epub ahead of print]. [abstract]