Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

lncRNA

Targeting lncRNA offer new opportunities for modulation of Wnt signaling pathways involved in stem cell renewal and differentiation.

Parasramka MA, Patel T. (2016) Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities. Stem Cell Investig 3:1. [article]

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