Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression profile in gastric cancer and its potential clinical value.
The global lncRNA expression profile in gastric cancer was measured by lncRNA microarray. The relationship between their levels and clinicopathological factors of patients with gastric cancer was explored. Total of 135 lncRNAs, which differential expression levels between tumor and non-tumorous tissues were more than twofold, were found (GEO No. GSE47850). A receiver operating characteristic (ROC) curve was constructed for differentiating gastric cancer from benign gastric diseases.
The lncRNA expression profile in gastric cancer suggests the potential roles of lncRNAs in gastric cancer occurrence and development. The overexpression of H19 in gastric cancer suggests that H19 may be participated in gastric cancer. The reduced expression of uc001lsz in gastric cancer cell lines and tissues, its associations with TNM stage, and its dysregulation in early cancer and precancerous lesions suggest that uc001lsz may be a potential marker for the diagnosis of early gastric cancer.
- Song H, Sun W, Ye G, Ding X, Liu Z, Zhang S, Xia T, Xiao B, Xi Y, Guo J. (2013) Long non-coding RNA expression profile in human gastric cancer and its clinical significances. J Transl Med 11(1), 225. [article]