Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen deprivation therapy (ADT) to have a better effect to fight against PCa, especially castration-resistant prostate cancer (CRPC). Here, researchers from Huaqiao University summarize the multicellular events controlled by ncRNAs and give a snapshot of future scientific activities and clinical applications.
Schematic map of the functions of lncRNAs
LncRNAs regulate gene expression via recruiting chromatin modifying complex, stabilize protein and mRNA via direct binding. LncRNAs still can titrate miRNAs levels.