The Basic Science Program (BSP) pursues independent, multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR)
Supported by the BSP, the Basic Research Laboratory (BRL), RT Biochemistry Section, under the scientific direction of Dr. Stuart LeGrice, combines structural, biochemical and biophysical approaches to study the retroviral enzymes and the nucleic acids with which they interact as potential therapeutic targets. This work is complemented by chemical biology approaches to identify small molecules that interact with, and antagonize, cellular and viral regulatory RNAs.
- Perform laboratory research on RNA genomes of hepadnaviruses, flaviviruses and filoviruses
- Perform hands-on benchwork with the expectation of producing first author papers
- Performance of a full range of experiments from molecular biology to structural biology
- Work will involve several projects aimed at obtaining atomic-level understanding viral genome structure
- Perform data analysis and structure determination of viral lncRNAs
- Study the effect of novel small molecules on herpesvirus replication
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education).
- Foreign degrees must be evaluated U.S. equivalency
- No experience required beyond the doctorate degree
- PhD in chemistry, biochemistry or biophysics
- Demonstrated experience in: experience in handling small molecule microarrays to identify RNA binding compounds
- Record of first-author publications
- Scientific writing and presentation skills
- Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
- Experience working in BL-4 biosafety conditions
- Knowledge of virology of herpesvirus such as KSHV and biology of lncRNA function
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